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مقالات فارسیISIکنفرانسهاژورنالها

Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice

محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 12، شماره: 6
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 170

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لینک ثابت به این مقاله:
https://civilica.com/doc/1545081

شناسه ملی سند علمی:

JR_AJP-12-6_006

تاریخ نمایه سازی: 7 آبان 1401

چکیده مقاله:

Objective: Neuroprotective and antioxidant effects of Ocimum basilicum (O. basilicum) against pentylenetetrazole (PTZ)-induced seizures were investigated. Materials and Methods: Mice were divided as follows: (Group ۱) Control, (Group ۲) PTZ, (Groups ۳-۵) ۵۰,۱۰۰ and ۲۰۰ mg/kg hydro-ethanolic (HE) extract, and (Groups ۶-۸) ۲۰۰ mg/kg ethyl-acetate (EAF), N-hexane (NHF) and water (WF) fractions. Minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) latencies were measured. Biochemical and histological studies were done.Results: MCS and GTCS latency in HE groups were longer than the PTZ group (p<۰.۰۵ to p<۰.۰۰۱). EAF and NHF prolonged the onset of MCS and GTCS (p<۰.۰۰۱). PTZ increased malondialdehyde (MDA) and dark neuron (DN) production while decreased thiol, catalase (CAT) and superoxide dismutase (SOD) (p<۰.۰۵ to p<۰.۰۰۱).  Pre-treatment by HE and all fractions of the plant attenuated MDA and DN while increased thiol, CAT and SOD (p<۰.۰۱ to p<۰.۰۰۱).Conclusion: EAF and NHF had anticonvulsant properties. The extract and fractions protected the brain from PTZ-induced oxidative damages and showed neuroprotective effects.

کلیدواژه ها:

Neuroprotective ، Ocimum basilicum ، Oxidative stress ، Pentylenetetrazole ، Seizures

نویسندگان

Somaieh Mansouri

Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Mahmoud Hosseini

Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Alipour

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Farimah Beheshti

Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

Hassan Rakhshandeh

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Science, Mashhad, Iran.

Abbas Mohammadipour

Department of Anatomy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Akbar Anaeigoudari

Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran

Mohammad Jalili-nik

Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Reza Khazdair

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Amirali Jahani

Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran