Effects of aspirin on adverse pregnancy outcome in patients with abnormal aneuploidy screening biochemistry tests: A randomized clinical trial

Background: The aim of the present study was to study the effects of low dose aspirin on preventing any Adverse Pregnancy Outcome (APO) in women with aneuploidy abnormal screening tests in the second quarter and to compare the effects of aspirin on normal and abnormal Doppler.Methods: The current clinical trial study was performed on pregnant women with abnormal aneuploidy screening tests and normal Karyotype at the gestational age ۱۵-۱۸ week. Participants consisted of ۸۳ individuals in aspirin-receiving group and ۸۴ persons in control group. Doppler ultrasound was simultaneously performed to survey the Doppler results. Any APO was compared between the two groups.Results: The frequency of APO was ۳۲.۸% in aspirin-receiving group and ۴۱.۷% in control group (P=۰.۰۱, RR=۰.۴۳۸). The frequencies of preterm delivery before the ۳۷th week were۸.۰۷% in the group receiving aspirin with normal Doppler and ۳۲.۷% (P=۰.۰۲) in the control group. The frequency of NICU reception with normal Doppler was ۵.۸% in the aspirin group and ۱۹.۷% in control group (P=۰.۰۱). APO frequency in the group with many abnormal factors was ۱۱.۵% in the group receiving aspirin and ۵۳.۸% in control group (P=۰.۰۱). APO frequency in abnormal Doppler group was found to be ۴۶.۷% in the group receiving aspirin and ۵۰% in the control group (P=۰.۸۴, RR=۰.۱۱۲). Conclusion: Low dose of aspirin reduced APO. It reduced preterm delivery and reference of pregnant women to NICU with abnormal aneuploidy screening tests.