The Effects of Vitamin D۳ in Pediatric Patients Undergoing Congenital Heart Surgery
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 130
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شناسه ملی سند علمی:
JR_SBMU-5-2_012
تاریخ نمایه سازی: 9 آبان 1401
چکیده مقاله:
Background: To investigate the effects of vitamin D۳ on the surgical outcome of pediatric patients undergoing cardiac surgery for congenital heart conditions.Materials and Methods: Ninety pediatric cardiac surgery patients referred for preoperative evaluation were enrolled. Patients with insufficient vitamin D۳ levels received intramuscular vitamin D۳ (۳۰۰,۰۰۰ IU) three days before the surgery and those with final vitamin D۳ level of ≥۳۰ ng/dl were included and divided into ۳ groups (Group A: abnormal Vit D levels, no Vit D treatment; Group B: abnormal Vit D levels, Vit D treatment up to normal serum Vit D levels before surgery; Group C: normal baseline Vit D levels, no supplemental Vit D treatment). Interleukin ۱, ۶, ۱۰, tumor necrosis factor-alpha, vital signs, and arterial blood gas parameters were measured before the surgery and at ۶ and ۲۴ hours after cardiopulmonary bypass. Data on total hospital stay, reoperation rates, and inotropes scores were retrieved. Additionally, postoperative measures including hemodynamic factors, blood pressure, heart rate, cardiac output, electrocardiography changes, chest-tube drainage, and ventilation-related factors (i.e. respiratory rate, arterial blood gas, respiratory resistance, intubation time, …) were recorded.Results: We observed a significant increase in post cardiopulmonary bypass levels of IL-۱۰ and IL-۶ in all groups (p<۰.۰۰۲) regardless of vitamin D treatment status; however, no significant difference was seen in levels of IL-۱ and TNF-alpha. Groups B had more patients with critical levels of VIS scores compared to groups A and C (p<۰.۰۰۲). Furthermore, no differences in hemodynamic and metabolic parameters were observed.Conclusion: No significant difference in the rates of postoperative parameters in patients with normal and those with deficient levels of vitamin D۳ was observed.
کلیدواژه ها:
Vitamin D ، Congenital heart disease (CHD) ، Cardiac surgery ، Cardiopulmonary bypass ، Vitamin D۳ supplementation
نویسندگان
Hossein Ali Jelveh-Moghaddam
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kamal Fani
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Manouchehr Hekmat
Department of Cardiovascular Surgery, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amir A.Azari
Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran