Alkaline Phosphatase Profile of Patients with Fibro-Osseous Lesions

Introduction:Although some studies on craniofacial fibro-osseous lesions have assayed serum alkaline phosphatase levels of affected patients, the findings of these reports are often inconclusive. The aim of this study was to determine the association between the serum ALP levels of individuals with craniofacial fibro-osseous lesions (CFOLs) and treatment outcome.Materials and Methods:Consecutive patients who presented at the Ahmadu Bello University Teaching Hospital, Zaria from May, ۲۰۱۶ to December, ۲۰۱۷ with lesions histologically diagnosed as CFOLs. The Speight and Carlos’ (۲۰۰۶) classification of CFOLs was adopted, and the serum ALP level of patients and their age- and- gender matched apparently healthy controls were measured at presentation, and repeated at the ۳rd and ۶th post-operative months for subjects only. Treatment outcomes were assessed ۶ months post treatment.Results:Fifty cases of CFOLs were recorded with a male preponderance, while fibrous dysplasia was the most prevalent lesion, and the maxilla was the most affected jaw (۶۲%). Only ۱۱ subjects had elevated serum ALP levels at presentation, and the mean serum ALP level of subjects with CFOLs was higher (۳۴۱.۲ ± ۱۹۸.۱ IU/L) than that of their age-and gender-matched controls (۱۹۰.۷ ± ۱۱۰.۲ IU/L). With the exception of subjects whose lesions recurred, there was a decrease in the mean serum ALP levels of subjects by the ۳rd (۲۴۵ ± ۱۷۰.۲ IU/L) and ۶th (۲۴۰.۵ ± ۱۷۲.۷ IU/L) months post-treatment. Thirty three subjects had elimination of lesions, while three cases each recurred or developed morbidity.                     Conclusion:The treatment outcomes of patients with fibrous dysplasia appear to be associated with their serum ALP level. Therefore, serial serum ALP level monitoring suggested in the management of patients with fibrous dysplasia of the craniofacial region.