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مقالات فارسیISIکنفرانسهاژورنالها

Comparative treatment with HBO in a model of systemic loxoscelism in rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 12
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 203

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لینک ثابت به این مقاله:
https://civilica.com/doc/1553788

شناسه ملی سند علمی:

JR_IJBMS-25-12_006

تاریخ نمایه سازی: 25 آبان 1401

چکیده مقاله:

Objective(s): Spiders of the Loxosceles genus, known as violin spiders, produce venom with dermonecrotic and systemic effects, as it is a species widely distributed in the world, its study represents a high medical relevance. Systemic loxoscelism, which occurs in ۱ in ۵ cases and is the most frequent in children, can be fatal, so the study of effective therapy is of great relevance. In the present study, we compared different therapeutic options to mitigate the systemic effects of Loxosceles boneti venom in a model in which prepubertal rats were used.Materials and Methods: A model of systemic intoxication by L. boneti venom was provoked in male Wistar rats. Study groups were formed: healthy control, with venom and untreated control, treatment with N-acetylcysteine, and/or hyperbaric oxygenation therapy. Subsequently, pathological analysis of the kidney and lung was performed. The oxidant-antioxidant response was evaluated, and molecular analysis of the COX-۱ and COX-۲ enzymes was performed.Results: Regenerative changes were observed at the cellular level in both treatments, being more noticeable in the HBO group. The anti-oxidant response was outstanding in the same group. Conclusion: Both treatments offer considerable benefits, however; further studies are needed to provide adequate therapeutics.

کلیدواژه ها:

Antioxidant therapy ، Cyclooxygenases ، Hyperbaric oxygen therapy ، Spider venoms ، Systemic inflammatory-response

نویسندگان

Mireille Toledo-Blas

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Antonio Franco-Vadillo

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Selma Somilleda-Ventura

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Brenda Dominguez-Ruiz

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Gustavo Guevara-Balcazar

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Alexandre Kormanovski-Kovzova

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Pedro Lopez-Sanchez

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Rosa Jarillo-Luna

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Eleazar Lara-Padilla

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

Maria Castillo-Hernandez

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politecnico Nacional, México, City

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