Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson’s disease
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 158
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شناسه ملی سند علمی:
JR_IJBMS-26-2_002
تاریخ نمایه سازی: 8 دی 1401
چکیده مقاله:
Objective(s): Parkinson’s disease (PD) is one of the most incurable, chronic, and progressive neurodegenerative disorders Worldwide. Curcumin, a natural polyphenolic antioxidant compound, has a long history in traditional medicine. We investigate the effect of curcumin on brain oxidative stress, DNA fragmentation, and motor changes in rotenone-induced PD in mice. The possible modulation of the anti-parkinsonian action of drugs L-dopa and rasagiline by curcumin was also studied.Materials and Methods: Mice received rotenone ۱.۵ mg/kg and were treated with curcumin (۱۵۰ mg/kg), L-dopa (۲۵ mg/kg), rasagiline (۱ mg/kg), L-dopa+curcumin, or rasagiline+curcumin. Striatal malondialdehyde, reduced glutathione, nitric oxide, tyrosine hydroxylase, and brain DNA fragmentations were measured. Histopathological examination of brain tissues was done. Motor coordination and behavioral tests such as wire-hanging, stair, and wood-waking tests were included.Results: Rotenone caused elevation in brain malondialdehyde and nitric oxide contents, depletion of reduced glutathione accompanied by a reduction in rearing behavior, and impairment of motor activity in wire-hanging, stair, and wood-waking tests. Also, severe DNA fragmentation in the striatum, marked decrease of substantia nigra pigmented neurons, neuronal degeneration in the cerebral cortex and hippocampus, decreased glial fibrillary acidic protein reaction (GFAP) and glial cell size in the cerebral cortex were caused by rotenone. In rotenone-treated mice, brain oxidative stress was decreased by curcumin, L-dopa, rasagiline, curcumin+L-dopa, and curcumin+rasagiline. These treatments also prevented DNA fragmentation and markedly improved the motor and behavioral impairment caused by rotenone. Rotenone-induced histopathological changes were ameliorated by curcumin which had an additive effect to that of l-dopa or rasagiline.Conclusion: These data indicate that curcumin showed additive neuroprotective effects to L-dopa or rasagiline and ameliorated neurodegeneration, DNA fragmentation, and motor defects caused by rotenone in mice.
کلیدواژه ها:
نویسندگان
Marwa El-Shamarka
Department of Narcotics, Ergogenics, and Poisons, Medical Research Division, National Research Centre, Cairo, Egypt
Omar Abdel-Salam
Department of Narcotics, Ergogenics, and Poisons, Medical Research Division, National Research Centre, Cairo, Egypt
Nermeen Shafee
Department of Pathology, Medical Research Division, National Research Centre, Cairo, Egypt
Hala Zeidan
Department of Research on Children with Special Needs, Medical Research Division, National Research Centre, Cairo, Egypt
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