Analysis of non-carcinogenic health risk assessment of elemental impurities in vitamin C supplements
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 185
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شناسه ملی سند علمی:
JR_IJBMS-26-2_011
تاریخ نمایه سازی: 8 دی 1401
چکیده مقاله:
Objective(s): Elemental impurity exposure that may occur in the use of supplements has the potential to pose a risk to human health. Vitamin C supplements are among the most commonly used supplements on a daily basis and in the long-term due to the pharmacological properties of vitamin C. In this study, we aimed to evaluate the non-carcinogenic health risk of elemental impurities that may cause contamination in orally administered vitamin C supplements.Materials and Methods: Ten elemental impurities (Cd, Pb, As, Hg, Co, V, Ni, Cr, Sb, and Sn) in ۱۲ supplements were analyzed using ICP-MS. The estimated daily intake (EDI), hazard quotient (HQ), and hazard index (HI) values of elemental impurities were calculated for non-carcinogenic risk assessment. Cancer risk (CR) was additionally calculated for elemental impurities with carcinogenic properties detected in the samples.Results: Low levels of Cr and Hg were detected in some samples. While the HQ values of sample ۱, sample ۲, sample ۸, and sample ۹ for Hg were calculated as ۰.۰۵۴, ۰.۰۹۶, ۰.۰۶۴, and ۰.۰۸۶, respectively, the HQ values of sample ۵, sample ۱۰, and sample ۱۱ for Cr were calculated as ۰.۰۱۱, ۰.۰۱۷, and ۰.۰۱۴, respectively. Since only Hg or only Cr was detected in samples with elemental impurity, the HI values in the samples are the same as the HQ values. Since the HQ and HI values calculated from the samples are not≥۱, there is no elemental impurity at a level that will hazard human health through supplement use. Other carcinogenic elements were not detected in the samples except Cr. In sample ۵, sample ۱۰, and sample ۱۱, the CR values for Cr were ۱.۷۶۷.۱۰-۵, ۲.۵۷۱.۱۰-۵, and ۲.۰۸۹.۱۰-۵, respectively. In probability simulation, while HQ and CR values of Cr did not exceed the allowable value, the HQ level for Hg in the ۹۵% slice was higher than the allowable value.Conclusion: There is no risk to human health and there is no critical difference between the supplements considering the elemental pollutant content among the vitamin C supplements of different trademarks. However, in order to keep the Hg level, which has a potential risk capacity, at low limits, it is recommended that the necessary risk-reducing measures be taken by the authorities and further studies be carried out.
کلیدواژه ها:
نویسندگان
Fadime Canbolat
Department of Pharmacy Services, Vocational School of Health Services, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
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