Synthesis and Characterization with Antimicrobial Studies of mixed Curcumin Schiff Base –L-dopa with Divalent Cations Complexes

In the present article, mixed ligand metal (II) complexes have been synthesized with Schiff base (۱E, ۵Z, ۶E)-۱,۷ bis (۴-hydroxy-۳-methoxyphenyl)-۵-(۳-hydroxyphenyl) imino) hepta-۱,۶-dien-۳-one derived from Curcumin and ۳-aminophenol as primary ligand and L-dopa as a secondary ligand. The Schiff base act as bidentate and arrange to the metals through the azomethine (C=N) nitrogen and (C=O) oxygen atom. The mode of bonding of the Schiff base has been affirmed on the infrared by the UV-Visible, ۱H, and ۱۳C NMR spectroscopic techniques. The magnetic susceptibility and the UV-Vis data of the complexes propose octahedral geometry around the central metal ion. The information appears that the complexes have the structure of [L-M-(L-dopa)] system, where M=Mn(II), Ni(II), Cu(II), Zn(II) and Cd(II). The low conductance of all complexes supports the non-electrolytic nature of the complexes. The biological activity of the complexes was screened against bacteria, (Klebsiella and P. Staphylococuse and gives a good results anti-fungus C. Albicans). All complexes possess the biological activity which has the same activities, and good antimicrobial activity that displays higher activities against fungus compared with bacteria.