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مقالات فارسیISIکنفرانسهاژورنالها

Coding Variants of the FMO۳ Gene Are Associated with the Risk of Chronic Kidney Disease: A Case-Control Study

محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 11، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 143

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لینک ثابت به این مقاله:
https://civilica.com/doc/1581681

شناسه ملی سند علمی:

JR_RBMB-11-3_009

تاریخ نمایه سازی: 18 دی 1401

چکیده مقاله:

Background: Chronic kidney disease (CKD) is a global health concern involving roughly one-tenth of developed countries' populations. The flavin-containing dimethylaniline monooxygenase ۳ (FMO۳) gene encodes an enzyme that catalyzes trimethylamine N-oxide (TMAO), a toxin in CKD sufferers. This preliminary study aims to evaluate the association between coding region variations of FMO۳, rs۲۲۶۶۷۸۲G/A (E۱۵۸K), rs۲۲۶۶۷۸۰A/G (E۳۰۸G), and rs۱۷۳۶۵۵۷G/A (V۲۵۷M), and the susceptibility to CKD. Methods: A total of ۳۵۶ participants were enrolled, including ۱۵۷ patients diagnosed with CKD and ۱۹۹ age-matched healthy individuals. Genotyping of FMO۳ gene variations was performed via PCR-RFLP and ARMS-PCR methods. Results: Our findings revealed a significant association between rs۲۲۶۶۷۸۰A/G and rs۱۷۳۶۵۵۷G/A and CKD under different genetic models. Compared to the GGG haplotype of rs۲۲۶۶۷۸۲/rs۱۷۳۶۵۵۷/rs۲۲۶۶۷۸۰, the GAG, GAA, AAG, and AAA haplotype combinations conferred an increased risk of CKD in our population. Interaction analysis revealed that some genotype combinations, including GA/AA/AA, AA/AA/AA, GA/AA/GA, and GG/AG/AA, dramatically increased CKD risk in the Iranian population. No correlation was found between FMO۳ polymorphisms and CKD stages. Conclusions: These observations highlight the potential impact of coding variants of the FMO۳ gene on the onset of CKD. Further investigations into expanded populations and diverse races are needed to confirm our findings.

کلیدواژه ها:

Keywords: Chronic kidney disease ، FMO۳ ، Genetic variant ، Single-nucleotide polymorphism ، Trimethylamine N-oxide.

نویسندگان

Ismail Shorudi Dadi

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Me

Ramin Saravani

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Me

Tahereh Khalili

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Me

Saman Sargazi*

۲: Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.

Mahdi Majidpour

Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Me

Mohammad Sarhadi

Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.

Shekoufeh Mirinejad

Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.

Sheida Shahraki

Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.

Ali Alidadi

Department of Nephrology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Clinical Immunology Research Center (CIRC), Zahedan University of Medical Sciences, Zahedan, Iran.

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  • Aref HF, Naji NA, Ibrahim HD. Evaluation of Serum Cyclooxygenase, ...
  • Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, ...
  • Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, ...
  • https://doi.org/۱۰.۱۰۱۶/S۰۱۴۰-۶۷۳۶(۱۶)۳۱۵۷۵-۶Chand S, Chue CD, Edwards NC, Hodson J, Simmonds MJ, ...
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  • Sargazi S, Mollashahi B, Sargazi S, Heidari Nia M, Saravani ...
  • Sargazi FM, Alidadi A, Taheri H, Nia MH, Sargazi S, ...
  • Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution ...
  • Xu J, Guo Z, Bai Y, Zhang J, Cui L, ...
  • Garcia-Garcia G, Jha V. Chronic kidney disease in disadvantaged populations. ...
  • Jahantigh D, Mirani Sargazi F, Sargazi S, Saravani R, Ghazaey ...
  • Sargazi S, Heidari Nia M, Mirani Sargazi F, Sheervalilou R, ...
  • Stubbs JR, House JA, Ocque AJ, Zhang S, Johnson C, ...
  • Robinson-Cohen C, Newitt R, Shen DD, Rettie AE, Kestenbaum BR, ...
  • Bell JD, Lee J, Lee H, Sadler PJ, Wilkie D, ...
  • Mackay RJ, McEntyre CJ, Henderson C, Lever M, George PM. ...
  • Koukouritaki SB, Poch MT, Henderson MC, Siddens LK, Krueger SK, ...
  • Phillips IR, Shephard EA. Drug metabolism by flavin-containing monooxygenases of ...
  • Galavi H, Mollashahee‐Kohkan F, Saravani R, Sargazi S, Noorzehi N, ...
  • Galavi H, Noorzehi N, Saravani R, Sargazi S, Mollashahee-Kohkan F, ...
  • Li W, Zhu L, Huang H, He Y, Lv J, ...
  • Loktionov A. Common gene polymorphisms and nutrition: emerging links with ...
  • Damtie S, Biadgo B, Baynes HW, Ambachew S, Melak T, ...
  • Pagels AA, Söderkvist BK, Medin C, Hylander B, Heiwe S. ...
  • Florkowski CM, Chew-Harris JS. Methods of estimating GFR-different equations including ...
  • MWer S, Dykes D, Polesky H. A simple salting out ...
  • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis ...
  • Phillips IR, Shephard EA. Flavin-containing monooxygenase ۳ (FMO۳): genetic variants ...
  • Shephard EA, Treacy EP, Phillips IR. Clinical utility gene card ...
  • https://doi.org/۱۰.۱۰۳۸/ejhg.۲۰۱۴.۲۲۶Wei H, Zhao M, Huang M, Li C, Gao J, ...
  • Shan Z, Sun T, Huang H, Chen S, Chen L, ...
  • Hernandez D, Janmohamed A, Chandan P, Phillips IR, Shephard EA. ...
  • Dolphin CT, Janmohamed A, Smith RL, Shephard EA. Missense mutation ...
  • Teft WA, Morse BL, Leake BF, Wilson A, Mansell SE, ...
  • Shih DM, Wang Z, Lee R, Meng Y, Che N, ...
  • Allerston CK, Shimizu M, Fujieda M, Shephard EA, Yamazaki H, ...
  • Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, ...
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