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Synthesis of a stimuli-sensitive PEGylated nanoniosomal doxorubicin for the treatment of acute myeloid leukemia: An in vitro study

محل انتشار: مجله علوم نانو، دوره: 10، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 194

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1581722

شناسه ملی سند علمی:

JR_NAMJ-10-1_008

تاریخ نمایه سازی: 18 دی 1401

چکیده مقاله:

Objective(s): One of the effective strategies for targeted chemotherapy of cancer is the use of lipid nanocarriers. In this study, an optimal formulation of niosomal drug containing doxorubicin was developed to monitor the potency against cancer cells. Materials and Methods: In this experimental study, niosomal vesicles were prepared using phosphatidylcholine (۲۰%), span۶۰ (۵۲.۵%), cholesterol (۲۲.۵%), and DSPE-PEG۲۰۰۰ (۵%) by the thin-film method. Doxorubicin was loaded into the niosomes using an inactive loading method. Results: The features and characteristics of the nanocarrier were evaluated using Zeta-Sizer, SEM, FTIR, drug release, cellular uptake, and the cytotoxicity of the nanodrug carrier system by the MTT method. Niosomal vesicles-containing doxorubicin showed a size of ~۱۵۶.۸ nm, drug encapsulation efficiency of ~۹۴.۱۸%, zeta potential of ~-۳.۵۲ mV, and polydispersity index (PDI) of ~۰.۲۶۵. The prepared niosomes indicated a drug-controlled release system and FTIR analysis showed no interaction between nanocarriers containing drug and doxorubicin. Moreover, morphological examination of nanocarriers using SEM microscopy revealed that they had spherical structures. Also, cellular studies showed that drug toxicity was higher in encapsulated form of the drug compared with non-encapsulated doxorubicin which was confirmed by the cellular uptake results. Conclusion: The results confirmed the proper physicochemical characteristics of these nanocarriers that significantly increased the toxicity of the encapsulated drug against the KG-۱ cell line. It seems niosomal nanocarriers can be considered suitable carriers for drug delivery to cancer cells.

کلیدواژه ها:

Acute myeloid leukemia ، Doxorubicin ، KG۱ cell line ، Niosomes

نویسندگان

Fatemeh Bahrami-Banan

Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Science, Yazd, Iran

Mohammad Hasan Sheikhha

Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Science, Yazd, Iran

Nasrin Ghasemi

Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Science, Yazd, Iran

Masoumeh Rahmani

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mahdie Hemati

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Mohammadreza Safdari

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Fatemeh Haghiralsadat

Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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