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Angiography; an Inducer of TGF-Β during Early Atherosclerosis

محل انتشار: مجله فیزیک پزشکی ایران، دوره: 20، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 175

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لینک ثابت به این مقاله:
https://civilica.com/doc/1581758

شناسه ملی سند علمی:

JR_IJMP-20-1_007

تاریخ نمایه سازی: 18 دی 1401

چکیده مقاله:

Introduction: Angiography is an X-ray-based technique for the diagnosis of disorders of the arteries, veins, and heart chambers. X-ray is a potential factor for the modulation of immune responses, including cytokines, the key molecules that participate in cardiovascular disease pathogenesis. Due to the potential roles of interleukin-۶ (IL-۶) and transforming growth factor-beta (TGF-β) in cardiovascular disease, this study was designed to evaluate the IL-۶ and TGF-β serum levels before and after angiography in atherosclerosis suspected patients. Material and Methods: In this experimental study, the IL-۶ and TGF-β serum levels were explored, using the enzyme linked immunosorbent assay (ELISA) technique, in the healthy controls as well as three groups, including atherosclerosis suspected patients without, obstruction of ۱ and more than ۱ vessel. The IL-۶ and TGF-β serum levels also were evaluated before angiography and ۳ hours after angiography in the last three groups. SPSS software was used for data analysis. Results: The results showed that TGF-β serum levels were significantly higher in the controls in comparison of other groups (p> ۰.۰۰۱). Angiography and smoking increased TGF-β (p= ۰.۰۲۷) and IL-۶ (p= ۰.۰۳۵) serum levels, respectively, in atherosclerotic patients with obstruction of ۱ vessel. Age had a positive, moderate correlation with IL-۶ in the non-atherosclerotic patients (rs: ۰.۴۷۹, p= ۰.۰۳۹). Conclusion: Down-regulation of TGF-β may be associated with induction of inflammation in the patients. Angiography, via up-regulation of TGF-β, may reduce inflammation in the patients and smoking may increase the progression of atherosclerosis in atherosclerotic patients. Age may increase the risk of cardiovascular diseases via up-regulation of IL-۶.

کلیدواژه ها:

Angiography X ، Rays Interleukin ، ۶ Transforming Growth Factor ، Beta Atherosclerosis

نویسندگان

Faridesadat Khorasani

Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Laboratory Medicine, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ali Mehdipour

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Radiology, Faculty of Paramedicine, Rafsanjan University of Medical Sciences,

Mohammad Safarian

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences,

Yasaman Sohrani

Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Laboratory Medicine, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mehdi Zeinali

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences,

Mojtaba Mirzamohammadi

Dept. of Radiology, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ali Anbarian

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Dept. of Cardiology, Faculty of Medicine, Rafsanjan University of Medical Sciences,

Mohammad Kazemi Arababadi

Dept. of Laboratory Medicine, Faculty of Paramedicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical

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