The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome

Background: Green coffee seed (Coffea canephora) are rich in polyphenolic compounds and yellow turmeric (Curcuma domestica val.) is rich in curcuminoids and essential oils. This study determined the combination effect of green coffee seed and yellow turmeric extracts on TNF-α in acute respiratory distress syndrome (ARDS) in rat model.Methods: Thirty rats were randomly grouped into five equal groups of ۵ rats. Control group received normal diet and distilled water, positive control was administered with ۰.۸ mg/kg of LPS to induce ARDS in absence of any treatment, Treatment group ۱ received ۲۰۰ mg/kg/day of the combination of green coffe seed and yellow tumeric extract intraperitoneally (IP) for ۱۴ days, Treatment group ۲ was given ۴۰۰ mg/kg/day of the combination similarly, and treatment group ۳ was injected with ۶۰۰ mg/kg/day of the combination identically. TNF-α level wascompared between groups.Results: The combination of green coffee seed and yellow turmeric extract (۴۰۰ mg/kg/day) given for ۱۴ days could significantly decrease TNF-α level in rats after induction of ARDS (p˂۰.۰۵).Conclusion: A combination of green coffee seed (C. canephora) and yellow turmeric (C. domestica Val.) extract can be considered a therapeutic choice in ARDS.