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مقالات فارسیISIکنفرانسهاژورنالها

Frequency of Human Papillomavirus Genotypes in Head and Neck Epithelial Cancers in the Ear, Throat, and Nose Department of Shafa Hospital, Kerman, Iran in ۲۰۱۷

محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 28، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 125

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1582605

شناسه ملی سند علمی:

JR_JKMU-28-4_007

تاریخ نمایه سازی: 19 دی 1401

چکیده مقاله:

Background: Human papillomavirus virus (HPV) plays an important role in some human malignancies, including head and neck squamous cell carcinoma (SCC). However, it is necessary to evaluate the role of carcinogenic agents in local settings as well. Therefore, this study aimed to evaluate the frequency of HPV genotypes in head and neck epithelial cancers.Methods: In this case-control study, ۲۰۲ patients with suspected carcinoma referred to Shafa Hospital (Kerman, Iran, ۲۰۱۷) for pathological evaluation were enrolled. A definitive diagnosis of carcinoma was reported for ۱۰۱ patients (case group) and in the other ۱۰۱ subjects, carcinoma was not diagnosed. In order to determine the presence and type of HPV in tissue samples, the PCR method was used. Data analysis was performed using Fisher’s exact test, independent t-test, and logistic regression. Results: In total, ۲۷ head and neck SCC samples (۲۶.۷%) were positive for HPV DNA. In addition, the virus species were HPV-۱۱ in ۱۵ cases (۱۴.۹%), HPV-۱۶ and HPV-۱۸ in ۱۲ cases (۱۱.۹%), and HPV-۶ in ۱۰ cases (۹.۹%). According to the results, the presence of HPV was significantly higher in patients with SCC (P < ۰.۰۰۱). Moreover, smoking (P = ۰.۰۳) and opioid use (P < ۰.۰۰۱) were also significantly associated with SCC.Conclusion: The results of the present study demonstrated the presence of HPV in tissue samples of head and neck SCC patients in Kerman, Iran. Further studies are needed to investigate the preventive role of HPV vaccination in head and neck SCC.

کلیدواژه ها:

HPV ، Head and neck cancers ، Kerman

نویسندگان

Soolmaz Ghorbani

Department of Otorhinolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman, Iran

Hamidreza Mollaei

Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran

Tourajreza Mirshekari

Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran

Habibeh Ahmadipour

Department of Social Medicine, Kerman University of Medical Sciences, Kerman, Iran

Ali asghar Arabi mianroodi

Department of Otorhinolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman, Iran

Kimia Iranmanesh

Department of Otorhinolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman, Iran

Narges Khanjani

Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran

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