The Effect of GeriLact on Non-Alcoholic Fatty Liver Disease
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 135
فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JKMU-27-1_008
تاریخ نمایه سازی: 19 دی 1401
چکیده مقاله:
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which is correlated with overweight, obesity, and insulin resistance. Recently, the use of probiotics has been suggested for these patients as they have considerable outcomes. The aim of the present study is to evaluate the effect of GeriLact on patients with NAFLD. Method: In this randomized clinical trial, ۶۱ patients with NAFLD were recruited and randomly assigned to groups receiving GeriLact, ۵۰۰ mg, twice per day, or placebo (with the same dose) for sixty days. Weight, body mass index (BMI), lipid profile, fasting blood sugar (FBS), Alanine aminotransferase (ALT), Aspartate Aminotransferase (AST), and sonographic grading were evaluated before and at the end of the study. Results: In the GeriLact group, there was a significant decrease in ALT (p=۰.۰۰۲) and AST (p <۰.۰۰۱) levels, while the placebo group showed a significant decrease only in ALT level (p=۰.۰۱). There was a significant decrease in cholesterol levels in the intervention group compared to the placebo group (p=۰.۰۱), but there were no significant changes in FBS, triglycerides, LDL, and HDL levels between the two groups. The fatty liver grade was improved by ۶۳.۶% in the intervention group and by ۴۶.۴% in the placebo group. Conclusion: The results showed that probiotics caused significant improvement in ALT, AST, and cholesterol levels but had no effects on FBS, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Overall, treatment with GeriLact was found to be effective, safe, with low cost and well-tolerated in the long term use by the patients.
کلیدواژه ها:
نویسندگان
Mohammad Sadrkabir
Assistant Professor, Department of Internal Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
Shirin Jahed
Assistant Professor, Department of Internal Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Zahra Sadeghi
School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Khatereh Isazadeh
Associate Professor, Department of Community Medicine, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :