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The Effect of Curcumin on Functional and Structural Alterations of the Liver in Rats after MDMA Consumption

محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 26، شماره: 6
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 116

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1582715

شناسه ملی سند علمی:

JR_JKMU-26-6_005

تاریخ نمایه سازی: 19 دی 1401

چکیده مقاله:

Background: Nowadays, one of the problems of human beings is drug addiction, which causes individual, economic and social damages. One of the most commonly used substances in parties is ecstasy pills or ۳, ۴-methylenedioxymethamphetamine (MDMA). This study seeks to assess the effect of curcumin in complications of ecstasy on liver tissue in rats. Methods:۴۸ male Wistar rats in six groups were treated with curcumin (۲۰ µ mol/kg) and MDMA (۲۰ mg/kg) simultaneously and non-simultaneously. At the end of the experiment, blood samples were collected, lipid profile, liver enzymes were measured and morphology of liver was done. Results: MDMA consumption had adverse effect on lipid profile in comparison to the control group. Treatment of curcumin with MDMA consumption improved this effect of MDMA on lipid profile. Moreover, curcumin treatment concurrent with MDMA consumption increased liver enzymes, whereas consumption of MDMA for ۱۵ days and curcumin treatment in the next ۱۵ days decreased liver enzymes. Conclusion: Our findings suggest that simultaneous consumption of MDMA and curcumin have a synergistic adverse effect on liver enzymes and liver tissue. It is assumed that MDMA intestinal absorption increased by curcumin. While non-simultaneous treatment of curcumin and MDMA improved undesirable effects of MDMA on liver that is assumed by antioxidant capabilities of curcumin.

کلیدواژه ها:

Liver ، MDMA ، curcumin ، Rat

نویسندگان

Naser Khalaji

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Mohammad Hasan Khadem Ansari

Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Maryam Pourheydar

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Mehdi Hasanpour

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Sina Dindarian

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Mehdi Bagheri

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

leila chodari

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

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