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مقالات فارسیISIکنفرانسهاژورنالها

Prevalence of Alpha-۱ Antitrypsin (A۱AT) Deficiency among Patients with COPD in Kerman, Iran

محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 24، شماره: 2
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 114

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لینک ثابت به این مقاله:
https://civilica.com/doc/1583213

شناسه ملی سند علمی:

JR_JKMU-24-2_001

تاریخ نمایه سازی: 19 دی 1401

چکیده مقاله:

Background: One of the genetic risk factors for chronic obstructive pulmonary disease (COPD) is deficiency of Alpha-۱ Antitrypsin (A۱AT). There is no exact statistics about the prevalence of this disease in different regions of Iran. The present study aimed to determine the prevalence of alpha-۱ antitrypsin (A۱AT) deficiency in COPD patients in Kerman, Iran. Methods: In the present study, the serum level of AAT in ۲۹۴ COPD patients visited in the pulmonary clinic center in Kerman, Iran was measured. The diagnosis of COPD was confirmed through history taking and Spirometry before and after using Bronchodilator. Data analysis was done by using t-test and Chi-square test. Results: Among۲۹۴ studied patients, ۲۲۳ individuals (۷۵.۹%) were male. None of the patients had absolute deficiency of A۱AT, and only۱۳ patients (۴.۴%) had a relative deficiency of A۱AT. There was a statistically significant relationship between relative deficiency of A۱AT and the severity of COPD in a way that in most of the cases, relative deficiency of this enzyme was associated with severe and very severe airway obstruction. Conclusion: Based on the results of the present study and other similar studies in Iran, absolute and relative deficiency of A۱AT in Iran has less frequency compared to other regions of the world and other factors such as cigarette smoking, opium addiction and consumption of fossil fuels have a more significant role in the prevalence of COPD in Iran.

کلیدواژه ها:

Alpha-۱ Antitrypsin (A۱AT) ، Chronic Obstructive Pulmonary Disease (COPD) ، Prevalence

نویسندگان

Mitra Samareh Fekri

Associate Professor of Pulmonology‚ Cardiovascular Research Center‚ Institute of Basic and Clinical Physiology Sciences‚ Kerman University of Medical Sciences‚ Kerman‚ Iran

Sayed Mehdi Hashemi Bajgani

Assistant Professor of Pulmonology‚ Afzalipour Hospital Research Center‚ Kerman University of Medical Sciences‚ Kerman‚ Iran

Nasrollah Jamshidi Gohari

General Medicine‚ Physiology Research Center, Institute of Basic and Clinical PhysiologySciences, Kerman University of Medical Sciences, Kerman, Iran

Nasrin Bazargan Harandi

Assistant Professor of Pediatric Asthma and Allergy and Immunology‚ Afzalipour Hospital Research Center‚ Kerman University of Medical Sciences‚ Kerman‚ Iran

Mohammad Rahmatian

Vice Chancellor for Treatment‚ Kerman University of Medical Sciences, Kerman, Iran

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