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مقالات فارسیISIکنفرانسهاژورنالها

The effects of hormonal changes on sperm DNA integrity in oligoasthenoteratospermia individuals: A case-control study

محل انتشار: مجله طب تولید مثل ایران، دوره: 20، شماره: 12
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 135

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https://civilica.com/doc/1583911

شناسه ملی سند علمی:

JR_IJRM-20-12_001

تاریخ نمایه سازی: 20 دی 1401

چکیده مقاله:

Abstract Background: Hormonal imbalance is one of the important etiological factors for Oligoasthenoteratospermias (OAT). Objective: This study aimed to evaluate the effects of hormonal changes including prolactin, TSH, testosterone, luteinizing hormone, follicle-stimulating hormone and anti-Mullerian hormone on sperm DNA fragmentation in normal men compared with OAT to design a clinical algorithm for the comprehensive study of male factor infertilities. Materials and Methods: We consecutively selected ۶۰ candidates referred to the infertility clinic to collect the semen and blood samples. Then, a terminal deoxynucleotidyl transferase dUTP nick end labeling test was performed to evaluate the sperm DNA fragmentation index (DFI). After semen analysis and DFI checking, they were classified into ۴ groups consisting of normospermia and OAT men each with or without increased DFI. Hormone parameters were analyzed using enzyme-linked immunoassay. Results: Follicle-stimulating hormone and luteinizing hormone levels showed positive correlations with DFI in a significant way (p ≤ ۰.۰۱), while testosterone and thyroid-stimulating hormone were associated with sperm concentration. Prolactin and anti-Mullerian hormone levels significantly correlated (p ≤ ۰.۰۱) with sperm concentration and DFI value simultaneously. Conclusion: Decreased and increased levels of serum hormones could adversely affect semen profile and sperm DNA integrity which lead to severe male infertility. Although we investigated the effects of the main hormones related to male infertility on DNA damage, the role of these hormones on the fertilization rate and embryo quality needs to be evaluated in further studies.

کلیدواژه ها:

DNA fragmentation ، Oligospermia ، Asthenospermia ، Teratospermia ، Hormones ، شکست DNA اسپرم ، الیگواسپرمی ، استنواسپرمی ، تراتواسپرمی و هورمون ها.

نویسندگان

Zeinab Bahrami

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Laleh IVF Clinic, Laleh Hospital, Tehran, Iran.

Neda Daeifarshbaf

Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Infertility Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.

Fatemehsadat Amjadi

Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Reza Aflatoonian

Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Laleh IVF Clinic, Laleh Hospital, Tehran, Iran.

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