Protective Effect of Pomegranate Seed Oil against D-Galactose-Induced Aging in Rats
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 116
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شناسه ملی سند علمی:
JR_ZUMS-31-144_010
تاریخ نمایه سازی: 26 دی 1401
چکیده مقاله:
Background and Objective: Aging is a natural phenomenon which can cause changes in most organs and cells. Numerous mechanisms including oxidative stress and free radical generation is involved in the progression of the aging process. Pomegranate seed oil (PSO), has different therapeutic properties including anti-oxidant and anti-inflammatory effects. In this research, the effect of PSO against D-galactose-induced aging is investigated.
Materials and Methods: D-galactose, ۵۰۰ mg/kg, injected subcutaneously (S.C.) to induce aging in rats. Animals in treatment groups received PSO, ۰.۴ and ۰.۸ ml/kg intraperitoneally (i.p.). After ۴۲ days, behavioral test was evaluated by passive avoidance (PA). Then animals killed, blood samples collected by cardiac puncture, and brain and liver removed. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) measured in serum. Malondialdehyde (MDA) and thiol contents of brain and liver homogenized tissue samples were determined.
Results: D-galactose increased lipid-peroxidation in liver and brain tissues as well as elevation of ALT, AST, but the level of thiol contents decreased in homogenized tissues. Both doses of PSO attenuated d-galactose-induced injury in liver and brain by decreasing ALT, AST, MDA and elevation of thiol content. The PA test showed that PSO increased the latency time to enter the
dark chamber compared to the control group.
Conclusion: PSO decreased D-galactose-induced aging in rats via prevention of oxidative stress. This effect may be related to the presence of various compounds and their anti-oxidant properties, which is found in PSO.
کلیدواژه ها:
نویسندگان
Azar Hosseini
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Leila Ziaee
Dept. of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Arezoo Rajabian
Dept. of Internal Medicine, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Taher Boroushaki
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
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