Enantioselective Release Behavior of Ketoprofen Enantiomers from Alginate-metal Complexes, Monitored by Chiral HPLC
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 127
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شناسه ملی سند علمی:
JR_ANALCH-7-1_005
تاریخ نمایه سازی: 16 بهمن 1401
چکیده مقاله:
Alginate-metal complexes were prepared with divalent (Ca, Ba, Zn) and trivalent metals (Fe, Al) via congealing method in form of beads. Alginate mixed metals (Ca & Fe) complexes were also prepared by simultaneous and consecutive congealing. The studied beads were blank beads and racemic ketoprofen (KTP) loaded beads. Metal content was determined by atomic absorption spectroscopy and was ۱.۸% to ۳۰.۴%. IR spectra were registered and showed interaction between ketoprofen carboxylic OH and alginate hydroxyl OH, thus chiral interaction is suggested. Chiral HPLC was used to monitor enantioselective release (ESR) of racemic ketoprofen enantiomers in a phosphate buffer solution (PBS) at pH=۷.۴.ESR is expressed as the relative chromatographic area of R-enantiomer to S-enantiomer (R/S ratio). For divalent metal complexes, over the first ۵۰ min of release, R/S was < ۱; with starting value (۰.۵۳) in case of calcium, indicating important ESR, but less important in case of barium. However, in case of zinc R/S was >۱ with starting value of ۱.۱, indicating weak ESR. No significant results of ESR were obtained for trivalent metal complexes, where R/S is almost ۱ in case of iron and aluminum. For alginate beads which simultaneously congealed with (Ca & Fe), R/S was >۱. Nevertheless, consecutively congealed alginate gave opposite ESR behavior; R/S was ۱ for Fe then Ca congealed alginate.
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نویسندگان
Ghaidaa Alkhayer
Department of chemistry, Faculty of sciences, Damascus university, Syria.
Hussein Khudr
Research Institute for Pharmaceutical and Chemical Industries, Scientific studies and research centre, Damascus, Syria.
Yahya Koudsi
Department of chemistry, Faculty of sciences, Damascus university, Syria
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