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مقالات فارسیISIکنفرانسهاژورنالها

Comparison of Anti-Inflammatory and Anti-Infection Impact of Cornelian Cherries, Sucralfate, and Intravesical Hyaluronic Acid in a Rat Model of Interstitial Cystitis

محل انتشار: فصلنامه تحقیقات بین رشته ای در اورولوژی، دوره: 4، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 192

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لینک ثابت به این مقاله:
https://civilica.com/doc/1600273

شناسه ملی سند علمی:

JR_TUMS-4-3_004

تاریخ نمایه سازی: 19 بهمن 1401

چکیده مقاله:

Introduction: To assess the effects of treatment with oral Cornu’s mas and sucralfate, and intravesical hyaluronic acid (HA) on bladder histopathology and inflammatory cells in vivo model of Bladder pain syndrome/interstitial cystitis (BPS/IC).  Methods: A total of ۲۵ female rats were grouped: control (group I), IC (group II), HA (group III), Sucralfate (group IV), and Cornu’s mas (group V). Chemical cystitis was induced in four groups (all except the control group) by the intravesical instillation of Hydrogen peroxide, Cornu's mas extract for ۷ days twice a day, sucralfate for seven days twice a day, and HA every week for a month and then every month for two months were administered. Bladder tissue was removed to check inflammatory cell infiltration by histopathological examination.Results: None of the three treatment groups recorded any case of erosion and ulcer, and considering edema, group III recorded one severe case and three mild/moderate cases; and groups IV and V were comprised of mild/moderate cases. Both leukocyte count and mast cell count were significantly higher in group II (P-value=۰.۰۳۳) in comparison to group I. None of the treatments were able to regress the mast cell and leukocyte numbers to the level of the control group (all P-value>۰.۴).Conclusions: Intravesical injection of HA and oral administration of sucralfate, and Cornu’s mas were able to reduce the inflammation severity but not the normal level in the rat model of BPS/IC.

کلیدواژه ها:

Cornu’s Mas ، sucralfate ، Hyaluronic acid ، Interstitial Cystitis ، experimental

نویسندگان

Fateme Guitynavard

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Seyed Javad Mirjavadi

Department of Urology, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Mehdi Rakebi

Department of Urology, Ilam University of Medical Sciences, Ilam, Iran

Seyed Amin Mirsadeghi

Kasra Hospital, Tehran, Iran

Mahdi Khoshchehreh

Department of Pathology, University of California, Los Angeles, USA

Alireza Pakdel

Department of Urology, Tabriz University of Medical Sciences, Tabriz, Iran

Reza Mohammadi Farsani

School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mohammad Reza Rahimi

Taleqani Hospital, Mazandaran University of Medical Sciences, Mazandaran, Iran

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