A review on human reproductive systems encountering with the severe acute respiratory syndrome coronavirus ۲ infection

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 130

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شناسه ملی سند علمی:

JR_IJRM-21-1_001

تاریخ نمایه سازی: 24 بهمن 1401

چکیده مقاله:

The severe acute respiratory syndrome coronavirus ۲ (SARS-CoV۲) is the leading cause of the new deadly pneumonia named coronavirus disease ۲۰۱۹ (COVID-۱۹) pandemic. This pathogen has different co-receptors on various tissues, resulting in vast pathophysiological circumstances. Here, we present a comprehensive narrative review focusing on the impact of SARS-CoV۲ on human reproduction. Evidence-based literature revealed inconsistent results for this virus in the reproductive organs of patients with COVID-۱۹, even in the critical phase. Conversely, numerous satisfactory data represented those different reproductive activities, from gametogenesis to pregnancy, can be targeted by SARS-CoV۲. The severity of COVID-۱۹ depends on the differential expression of the host cellular components required to enter SARS-CoV۲. The cytokine storm and oxidative stress coming out during COVID-۱۹ are associated with complications in reproductive endocrinopathies. Men are naturally more susceptible to COVID-۱۹, especially accompanied by orchitis and varicocele. Synergistically the interaction of SARS-CoV۲ and female reproductive failures (polycystic ovary syndrome and endometriosis) increases the susceptibility to COVID-۱۹. Thus, pharmaceutical interventions that ameliorate the complications in individuals with reproductive disorders can be helpful to achieve good outcomes in assisted reproductive techniques. Soon, an increase in the infertility rate will likely be an overall impact of SARS-CoV۲ in patients who recovered from COVID-۱۹.

نویسندگان

Esmaeil Samadian

Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Bahman Aghcheli

Infection Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Roghaye Gharaei

Department of Obstetrics and Gynecology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Aligan Tabarraei

Infection Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

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