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مقالات فارسیISIکنفرانسهاژورنالها

Distribution of Epstein-Barr Virus and Human Herpesvirus ۸ Co-Infections among Human Immunodeficiency Virus -۱ Positive Patients

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 9، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 121

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لینک ثابت به این مقاله:
https://civilica.com/doc/1607531

شناسه ملی سند علمی:

JR_JIML-9-3_003

تاریخ نمایه سازی: 2 اسفند 1401

چکیده مقاله:

Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-۸ could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV and HHV-۸ in saliva specimens obtained from HIV-۱ infected Iranian individuals under the Highly Active Antiviral Therapy (HAART) regimen compared with naïve patients. Materials and Methods: A cross-sectional study was conducted on ۱۰۳ HIV-۱ positive patients who attended the hospitals affiliated with the Iran University of Medical Sciences, in Tehran, Iran, from ۲۰۱۸ to ۲۰۱۹. Enzyme-linked immunosorbent assay (ELISA) test was performed to evaluate HHV-۸ and EBV antibodies. A conventional polymerase chain reaction (PCR) was carried out on saliva samples to detect EBV infection and a nested-PCR assay for HHV-۸ infection. SPSS (version ۲۰) was used for statistical analysis. Results: Patients' mean age ± SD was ۴۳.۹ ± ۱۶ (range ۱۸-۸۲ years), and from among ۱۰۳ participants, ۵۹ (۵۷.۳%) were male. The results of PCR showed that HHV-۸ infection was found in ۱۹ (۱۸.۴%), and EBV infection was found in ۶۱ (۵۹.۲%) participants. Also, HHV-۸ antibody was detected in ۷۳ (۷۰.۹%), and EBV antibody in ۹۷ (۹۴.۲%) patients. A significant association was observed between patients under treatment with HAART and HHV-۸ DNA or EBV DNA infection in saliva. Conclusions: HIV-infected patients demonstrated a remarkable rate of EBV and HHV-۸ in saliva, which could have a great role in the shedding of viruses. Also, they may contribute to the establishment of further opportunistic infections and devastating complications.

کلیدواژه ها:

Epstein-Barr Virus ، HIV ، Human Herpesvirus ۸ ، Opportunistic infections ، ویروس نقص ایمنی انسانی ، عفونت های فرصت طلب ، عفونت همزمان

نویسندگان

آرزو مرجانی

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ۲ Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

خشایار حسامی زاده

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

فرح بخارائی سلیم

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

خدیجه خانعلیها

Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

محمدهادی کربلایی نیا

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

زهرا حبیب

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

مریم اسقائی

Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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