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مقالات فارسیISIکنفرانسهاژورنالها

The Effect of Sitagliptin on Inflammatory Mediators in the Ovary of Rat with Polycystic Ovary Syndrome

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 9، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 158

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لینک ثابت به این مقاله:
https://civilica.com/doc/1608205

شناسه ملی سند علمی:

JR_JIML-9-1_007

تاریخ نمایه سازی: 3 اسفند 1401

چکیده مقاله:

Background and Aims: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease in females of reproductive age and is a significant infertility cause. Inflammation plays a crucial role in the pathogenesis of PCOS. The present study evaluated whether sitagliptin, dipeptidyl peptidase-۴ inhibitor, attenuates inflammatory markers C-reactive protein (CRP), interleukin(IL)-۶, tumor necrosis factor-α (TNF-α), IL-۱β, and transforming growth factor-β (TGF-β) in a rat model of PCOS. Materials and Methods: Twenty-two female adult Wistar rats were randomly divided into four groups: control, PCOS model, PCOS+sitagliptin (۲۵ mg/kg), and PCOS+sitagliptin (۵۰ mg/kg). PCOS was induced by injection of estradiol valerate, intraperitoneally. Sitagliptin was gavaged daily for ۳۰ days to both groups of animals. After the treatment period, blood and ovaries tissue were collected to analyze inflammatory parameters. Results: The mRNA levels of IL-۶, IL-۱β, TGF-β, and TNF-α in the PCOS model group were markedly elevated compared with the control group (p<۰.۰۱). These parameters' mRNA levels were reduced in the sitagliptin treatment groups compared with the PCOS group (p<۰.۰۱). Also, the serum concentration of CRP in the PCOS group was more than the control. This increase significantly decreased in groups treated with sitagliptin compared with the PCOS group. Conclusion: The presented study suggested that the protective effects of sitagliptin on PCOS may be due to its inhibitory effect on expression and inflammatory markers' levels.

کلیدواژه ها:

C-reactive protein ، Interleukin-۶ ، Polycystic ovary syndrome ، Sitagliptin ، Transforming growth factor-β ، Tumor necrosis factor-α ، .

نویسندگان

آزاده صفاییان

Department of Physiology, Faculty of medicine, Shahid Sadoughy University of Medical Science, Yazd, Iran

مهین ایزدی

Department of Reproductive Biology, Yazd Institute for Reproductive Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

فاطمه زارع مهرجرد

Neuroendocrine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

مریم یادگاری

Department of Biology & Anatomical Sciences, Shahid Sadoughi University of Medical Sciences and Health Services, Faculty of Medicine, Yazd, Iran

محمد ابراهیم رضوانی

Department of Physiology, School of medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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