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مقالات فارسیISIکنفرانسهاژورنالها

Molecular Investigation of the Human Adenovirus in Retinoblastoma Patients

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 8، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 133

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1608749

شناسه ملی سند علمی:

JR_JIML-8-2_002

تاریخ نمایه سازی: 6 اسفند 1401

چکیده مقاله:

Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma ۱ interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma patient's tumors. Materials and Methods: In this study, we evaluated the HAdV infection in ۹۶ pathological confirmed retinoblastoma samples. The DNA was extracted from formalin-fixed paraffin-embedded blocks, and the virus infection was assessed using polymerase chain reaction. SPSS version ۲۲ was used for statistical analysis. Results: The mean age ± SD of the retinoblastoma patients was ۲۸.۸۹ ± ۱۷ months. In addition, the demographic evaluation indicated that ۴۳ (۴۶.۷%) of patients were female. The retinoblastoma laterality assessment indicates ۸۷ (۹۰.۴%) unilateral and ۹ (۹.۴%) bilateral tumors. Growth pattern analysis indicates endophytic ۵۸ (۷۷.۳%), exophytic ۸ (۱۰.۷%), and ۹ (۱۲%) of tumors with mix endophytic and exophytic patterns. The polymerase chain reaction results could not found any evidence of HAdV infection in all ۹۶ formalin-fixed paraffin-embedded samples. Conclusions: The study results suggest that there is not any association between HAdV infection and retinoblastoma tumors in studied samples. The HAdV infection may not a concern in retinoblastoma pathogenesis. Further investigations are recommended in this field of study.

کلیدواژه ها:

Human adenovirus ، PCR ، Retinoblastoma ، Tumors

نویسندگان

علیرضا طبیب زاده

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

مسعود ناصری پور

Eye Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

محمد هادی کربلایی نیا

Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran

داود جوانمرد

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

علیرضا صادقی پور

Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

مریم اسقایی

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

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