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مقالات فارسیISIکنفرانسهاژورنالها

RAGE p.۸۲G>S Polymorphism Is Not Associated with the Risk of Multiple Sclerosis in Iranian Population

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 7، شماره: 1
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 215

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لینک ثابت به این مقاله:
https://civilica.com/doc/1608812

شناسه ملی سند علمی:

JR_JIML-7-1_003

تاریخ نمایه سازی: 6 اسفند 1401

چکیده مقاله:

Background and Aims: Multiple sclerosis (MS) is known as a partially inheritable inflammatory autoimmune disease which involves the nervous system. Different studies suggest that immune dysregulation has an important role in the pathogenesis of MS, but its exact pathomechanism has not yet been explicated. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. In MS patients, the expression of membrane-bound RAGE on peripheral blood mononuclear cells, as well as the serum levels of the RAGE ligands are upregulated. Materials and Methods: In this case-control study, we evaluated the association between MS incidence and RAGE p.۸۲G>S polymorphism (rs۲۰۷۰۶۰۰) compared with healthy controls in an Iranian population. A total of ۱۵۸ patients and ۱۵۶ healthy blood donors were enrolled. This polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Results: Allele frequencies (p=۰.۳۱۹) and genotype distribution (p=۰.۳۱۵) of the RAGE p.۸۲G>S gene polymorphism in MS patients and controls were not significantly different. Conclusions: The present study indicated no relationship between RAGE p.۸۲G>S polymorphism and the risk of MS in Iranian population.

کلیدواژه ها:

Advanced glycation end product ، Multiple sclerosis ، Polymorphism

نویسندگان

حمیده ولی زاده

Department of Immunology, Faculty of Medicine, International Campus of Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

گیلدا اسلامی

Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

ریحانه رهنما

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran.

ابوالقاسم رحیم دل

Department of Neurology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

فاطمه السادات دشتی

Reproductive Immunology Reseach Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

رضا منصوری

Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

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