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مقالات فارسیISIکنفرانسهاژورنالها

Myeloid Cell Leukemia-۱ Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 6، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 131

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https://civilica.com/doc/1609600

شناسه ملی سند علمی:

JR_JIML-6-1_005

تاریخ نمایه سازی: 7 اسفند 1401

چکیده مقاله:

Background and Aims: Myeloid cell leukemia-۱ (Mcl-۱) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-۱ has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-۱ mRNA in myelodysplastic syndrome (MDS) patients and determined association with clinico-pathological factors, MDS subgroups as well as international prognostic scoring system. Materials and Methods: The relative level of Mcl-۱ was determined by real time quantitative real-time polymerase chain reaction and gene expression normalized to Glyceraldehyde-۳-phosphate dehydrogenase. Results: Results indicated amplification of mRNA encoding Mcl-۱ in ۱۰۰% of the cases. The higher level of Mcl-۱ existed in MDS patients compared with the healthy controls but there was no statistically difference of Mcl-۱ expression between these groups. Fold change in gene expression was higher in advanced stage MDS, high risk MDS, cases with >۵% blast and LDH >۴۰۰ to their corresponding groups. In addition, the correlation between gene expression and cytogenetic prognostic subgroups was statistically significant (p=۰.۰۴۳). Conclusions: In the present study, we showed that Mcl-۱ is expressed in MDS independent of the World Health Organization subgroup and international prognostic scoring system. Therefore, Mcl-۱ may be up-regulated already in early stages of leukemogenesis.

کلیدواژه ها:

Mcl-۱ ، Myelodysplastic syndromes ، Real time PCR

نویسندگان

فرهاد ذاکر

Department of Hematology, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

محمد جعفر شریفی

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Iran.

ناهید نصیری

Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

مرجان یغمایی

Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

سوده نامجو

Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

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