Antibiotic Resistance Patterns and Molecular Typing of Acinetobacter Baumannii Strains Isolated from Burn Patients in Iran
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 161
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شناسه ملی سند علمی:
JR_JIML-5-4_006
تاریخ نمایه سازی: 7 اسفند 1401
چکیده مقاله:
Background and Aims: Acinetobacter baumannii (A. baumannii) is an important multidrug-resistant opportunistic pathogen frequently causing various nosocomial infections and is a serious threat to burn patients. These infections are usually caused by the outbreak strains. The aim of this study was to show antibiotic resistance pattern and molecular typing of A. baumannii genes isolates collected from burn patients and also distribution of different types of burn patients.
Materials and Methods: In this study, ۳۰۷ different strains were detected. Totally ۱۰۰ A. baumannii strain was selected in burn center of Isfahan hospital. Antibiotic resistance pattern was determined by disk diffusion method (Kirby Bauer). The presence of genes coding in antibiotic resistance were analyzed by using multiplex-PCR method. The standard strains of Escherichia coli ATCC ۲۵۹۲۲ and A. baumannii ATCC ۱۹۶۰۶ were used as negative and positive controls.
Results: The antibiotic resistance pattern for A. baumannii showed high resistance for ciprofloxacin, ceftazidime, and tetracycline with frequency of ۸۲.۵%, ۷۵.۳%, ۷۲%, respectively. Moreover, the most sensitive antibiotics were chloramphenicol, and nitrofurantoin with the resistance frequency of ۳.۹% and ۲.۸%. CITM (۹۱.۱%) was the highest detected gene.
Conclusions: High prevalence of antibiotic resistance pattern among A. baumannii isolated from burn center hospitals indicates the important role of multidrug resistant isolates.
کلیدواژه ها:
نویسندگان
فهیمه نوربخش
Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
الهه تاج بخش
۲. Department of Microbiology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
دانا دانشمند
۳. Nosocomial Infection Research Center, Isfahan University of Medical Science, Isfahan, Iran
سمانه برونی
۴. Nourdanesh Institute of Higher Education, Meymeh, Esfahan, Iran
Vajiheh Nourbakhsh
Hazrat Fatemeh Zahra Hospital, Affiliated to the Treatment and Management of Social Security in Isfahan, Isfahan, Iran
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