The Effect of Adding Ondansetron and Metoclopramide to Intravenous Acetaminophen on Pain Control and Post-operative Nausea and Vomiting: A Randomized Double-blind Clinical Trial
محل انتشار: مجله مراقبت مبتنی بر شواهد، دوره: 13، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 115
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شناسه ملی سند علمی:
JR_EBCJ-13-1_003
تاریخ نمایه سازی: 20 فروردین 1402
چکیده مقاله:
Background: Pain and postoperative nausea and vomiting (PONV) are two common complications of laparoscopic cholecystectomy, highlighting the particular importance of increasing satisfaction among patients undergoing this surgery.Aim: This study was performed aimed to evaluate the effect of adding ondansetron and metoclopramide to intravenous acetaminophen on pain control and postoperative nausea and vomiting of patients undergoing laparoscopic cholecystectomy.Method: This double-blind clinical trial study was conducted in ۲۰۱۹ on ۸۳ patients in the central operating room of Ghaem Hospital in Mashhad, Iran. The patients were randomly assigned to three groups. The first and second groups received intravenous acetaminophen with ondansetron at doses of ۴ and ۸ mg, respectively, and the third group received intravenous acetaminophen with metoclopramide. Pain and PONV scores were measured postoperatively. Data were analyzed by SPSS (version ۲۵.۰) and GEE model, Chi-square, ANOVA and Kruskal-Wallis tests. P<۰.۰۵ was considered statistically significant.Results: Patients in the first and second groups experienced more pain than those in the third group at the time of entering the recovery, leaving the recovery, and ۶ h after the surgery (P<۰.۰۰۱). However, the PONV scores were not significantly different among the three groups (P=۰.۸۱۲).Implications for Practice: The co-administration of metoclopramide and acetaminophen was more effective than acetaminophen and ondansetron in controlling postoperative pain of laparoscopic cholecystectomy.
کلیدواژه ها:
نویسندگان
Mohsen Saber Moghaddamranjbar
Associate Professor, Department of Anesthesiology and Critical Care, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Amir Zoka
Department of Anesthesiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Jamshid Jamali
Assistant Professor. P h D in Biostatistics, Department of Biostatistics and Epidemiology, School of Public Health, Mashhad University of Medical Sciences, Mashhad, Iran
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