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مقالات فارسیISIکنفرانسهاژورنالها

Protective effects of melatonin receptor agonists on endotoxin-ınduced uveitis in rats

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 5
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 143

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لینک ثابت به این مقاله:
https://civilica.com/doc/1633297

شناسه ملی سند علمی:

JR_IJBMS-26-5_007

تاریخ نمایه سازی: 28 فروردین 1402

چکیده مقاله:

Objective(s): Melatonin has an important role in regulating a variety of physiological functions of the body. We investigated the protective effects of Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) in rats.Materials and Methods: ۷۰ rats were randomly divided into fourteen groups. Healthy group )normal saline, IP(, Uveitis group (۲۰۰  μg/kg lipopolysaccharide (LPS), SC), DEX group (۲۰۰  μg/kg LPS plus ۱  mg/kg dexamethasone, IP), AGO۲۰ group received ۲۰۰ μg/kg LPS plus ۲۰ mg/kg AGO, AGO۴۰ group received ۲۰۰  μg/kg LPS plus ۴۰  mg/kg AGO, RAME۲ group received ۲۰۰ μg/kg LPS plus ۲  mg/kg RAME, and group RAME۴ received ۲۰۰ μg/kg LPS plus ۴ mg/kg RAME. Each group had two subgroups: the ۳rd and ۲۴th hour. The eye tissues were collected and investigated biomicroscopically (clinical manifestations and scoring, molecularly(qRT-PCR analyses of Tumor Necrosis Factor-α (TNF-α), vascular endothelial growth factor(VEGF), and Caspase ۳ and Caspase ۹ mRNA expression), biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels) and histopathologically (staining with Harris Hematoxylin and Eosin Y).Results: Melatonin receptor agonist treatment reduced the clinical score count of ocular inflammation in the uveitic rats. TNF-α, VEGF, Caspase ۹, and Caspase ۳ levels markedly decreased in the uveitic rats. Melatonin receptor agonists significantly ameliorated fixed changes in GSH, SOD, and MDA levels. Melatonin receptor agonists also ameliorated histopathological injury in eye tissues associated with uveitis.Conclusion: Melatonin receptor agonists ameliorated the inflammatory response in EIU. These findings suggest that melatonin receptor agonists may represent a potential novel therapeutic drug for uveitis treatment.

کلیدواژه ها:

Lipopolysaccharides ، Melatonin ، Oxidative stress ، Rats ، Uveitis

نویسندگان

Tugba Nurcan Yuksel

Department of Pharmacology, Faculty of Medicine, Tekirdag Namık Kemal University, Tekirdag, Turkey

Muhammed Yayla

Department of Pharmacology, Faculty of Medicine, Kafkas University, Kars, Turkey

Duygu Kose

Department of Pharmacology, Faculty of Medicine, Sutcu Imam University, Kahramanmaraş, Turkey

Zekai Halici

Department of Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey

Erdinc Bozkurt

Department of Ophthalmology, University of Health Science, Ümraniye Education and Research Hospital, Department of Ophthalmology, Istanbul, Turkey

Erdem Toktay

Department of Histology and Embryology, Faculty of Medicine, Kafkas University, Kars, Turkey

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