Silica-Imidazole Solid Catalyst for N-Glycine Derivatives Synthesis

Schiff base was reacted with α-chloroacetic acid to produce N-(α-chlorobenzyl)-N-phenylglycine derivatives (N-Gly) over solid heterogeneous catalyst. Different N-Gly derivatives were synthesized over the catalyst with approximately ۹۰% yield. Both calculated and theoretical elemental analyses of N-Gly derivatives were in agreement with each other. The functional groups of N-Gly derivatives were proved by the FT-IR spectroscopy. The melting points N-Gly derivatives were matched with those in the literature. The catalyst was produced by immobilizing sodium silicate from rice husk with ۳–(chloropropyl)triethoxysilane followed by refluxed the product with p-xylyl-di-imidazolium chloride. The results showed that the optimum catalyst conditions were ۵ h as reaction time, ۰.۲۵ g mass of catalyst, ۹۰ °C as reaction temperature, and toluene as the best solvent.