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مقالات فارسیISIکنفرانسهاژورنالها

The Prognostic Value of HER۱ R۴۹۷K in the Management of Patients with Breast Cancer

محل انتشار: مجله تحقیقات سرطان، دوره: 6، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 105

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لینک ثابت به این مقاله:
https://civilica.com/doc/1645972

شناسه ملی سند علمی:

JR_MCIJO-6-4_002

تاریخ نمایه سازی: 16 اردیبهشت 1402

چکیده مقاله:

Introduction: Breast cancer is among the leading causes of cancer death in women. Despite extensive efforts to identify novel prognostic and predictive clinical biomarkers, a very small number of markers have been reported as risk stratification biomarkers (e.g., BRCA۱/۲ and HER۲). The substitution of arginine with lysine in codon ۴۹۷ of HER۱ ۴۹۷ has been suggested as a potential marker in breast cancer. This study attempted to explore the association between HER۱ ۴۹۷ gene polymorphisms with pathological and clinical information of breast cancer patients. Methods: ۱۱۰ breast cancer patients were recruited followed by genomic DNA extraction and genotyping using Taqman-PCR and sequencing. The associations of this genetic variant were evaluated with breast cancer risk and pathological information of patients.  Results: Our data showed that ۹.۴۳% of cases had AA genotype, while these frequencies in AC and CC genotypes were ۷۷.۳۵% and ۱۳.۲۰%, respectively. Moreover, we found that ۷۸.۴% of breast cancer patients with M۰ had AA+AC genotypes, while ۲۱.۶% of CC cases had M۰ status. Furthermore, ۲۲.۷% of these cases with CC genotype had N۰/۱. Interestingly, we observed that most of the patients with CC genotype had lower HER۲ expression. Conclusions: Our finding showed the potential association of CC genotype of HER۱ ۴۹۷ with the prognosis of patients with breast cancer. Further studies are warranted to explore the prognostic value of this marker in a larger and multi-center setting in breast cancer.

کلیدواژه ها:

Breast Neoplasms ، Genotype ، Biomarkers

نویسندگان

Masoomeh Baderi

۱) Department of Basic Sciences, Payam-e Noor University of Mashhad, Mashhad, Iran ۲) Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Soodabeh ShahidSales

Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Kazem Anvari

Cancer Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hassan Ramshini

Department of Biology, Payam-e Noor University, Branch of Sabzevar, Sabzevar, Iran

Shima Mehrabadi

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abolfazal Nosrati Tirkani

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mehrane Mehramiz

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Mahdi Hassanian

۱) Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ۲) Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Amir Avan

۱) Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ۲) Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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