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مقالات فارسیISIکنفرانسهاژورنالها

Hydrogel nanocomposite based on alginate/zeolite for burn wound healing: In vitro and in vivo study

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 6
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 174

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1650681

شناسه ملی سند علمی:

JR_IJBMS-26-6_013

تاریخ نمایه سازی: 21 اردیبهشت 1402

چکیده مقاله:

Objective(s): The main objective of the current assay was to evaluate the antibacterial and regenerative effects of hydrogel nanocomposite containing pure natural zeolite (clinoptilolite) integrated with alginate (Alg) as wound healing/dressing biomaterials.Materials and Methods: The zeolites were size excluded, characterized by SEM, DLS, XRD, FTIR, and XRF, and then integrated into Alg hydrogel followed by calcium chloride crosslinking. The Alg and alginate zeolite (Alg/Zeo) hydrogel was characterized by swelling and weight loss tests, also the antibacterial, hemocompatibility, and cell viability tests were performed. In animal studies, the burn wound was induced on the back of rats and treated with the following groups: control, Alg hydrogel, and Alg/Zeo hydrogel.Results: The results showed that the hydrodynamic diameter of zeolites was ۳۶۷ ± ۰.۲ nm. Zeolites did not show any significant antibacterial effect, however, the hydrogel nanocomposite containing zeolite had proper swelling as well as hemocompatibility and no cytotoxicity was observed. Following the creation of a third-degree burn wound on the back of rats, the results indicated that the Alg hydrogel and Alg/Zeo nanocomposite accelerated the wound healing process compared with the control group. Re-epithelialization, granulation tissue thickness, collagenization, inflammatory cell recruitment, and angiogenesis level were not significantly different between Alg and Alg/Zeo nanocomposite.Conclusion: These findings revealed that although the incorporation of zeolites did not induce a significant beneficial effect in comparison with Alg hydrogel, using zeolite capacity in hydrogel for loading the antibiotics or other effective compounds can be considered a promising wound dressing.

کلیدواژه ها:

Alginate ، Clinoptilolite ، Hydrogel ، Nanocomposite ، Wound healing ، Zeolite

نویسندگان

Hadi Samadian

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Reza Vahidi

Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran

Majid Salehi

Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Hossein Hosseini-Nave

Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Arman Shahabi

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

Saeed Zanganeh

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

Mahla Lashkari

Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran

Seyedeh Mehrnaz Kouhbananinejad

Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran

Nariman Rezaei Kolarijani

Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Seyed Mohammad Amini

Radiation Biology Research Center Iran University of Medical Sciences (IUMS) Tehran, Iran

Majid Asadi-Shekaari

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Mohamad Javad Mirzaei-Parsa

Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

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