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Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf۲/HO-۱ pathway

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 6
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 150

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لینک ثابت به این مقاله:
https://civilica.com/doc/1650688

شناسه ملی سند علمی:

JR_IJBMS-26-6_006

تاریخ نمایه سازی: 21 اردیبهشت 1402

چکیده مقاله:

Objective(s): Paraquat (PQ), a highly effective and rapidly non-selective herbicide, mainly targets the lungs and causes acute lung injury (ALI). So far, the scarcity of effective drug candidates against PQ-induced ALI remains a big challenge. Andrographolide (Andro), with its anti-inflammatory and antioxidant activities, has been demonstrated to alleviate ALI. Nevertheless, whether Andro could alleviate the PQ-mediated ALI remains unknown. Therefore, this study will explore the effects as well as the possible mechanism of Andro against ALI caused by PQ. Materials and Methods: C۵۷BL/۶J mice were injected with ۲۰ mg/kg PQ intraperitoneally to establish an ALI model. PQ-treated MLE-۱۲ cells were applied to a vitro model. Nuclear factor erythroid like-۲ (Nrf۲) was knocked out to explore the specific effects of the Nrf۲/ Heme oxygenase-۱ (OH-۱) pathway in the protection of Andro against ALI caused by PQ.Results: Andro significantly reduced lung damage and the ratio of Wet/Dry (W/D) weight, decreased MDA, IL-۶, IL-۱β, and TNF-ɑ levels, reversed the decrease of CAT and SOD levels, and inhibited apoptosis caused by PQ. Andro obviously increased the ratio of Bcl-۲/Bax while reducing caspase-۳ and cleaved caspase-۳ levels. Furthermore, Andro dramatically elevated the antioxidant proteins Nrf۲, NQO-۱, and HO-۱ levels compared with the PQ group. This experiment demonstrated that Andro reduced ROS and inhibited apoptosis, induced by PQ in MLE-۱۲ cells, by inducing Nrf۲/HO-۱ pathway activation.Conclusion: Andro effectively ameliorates oxidant stress and apoptosis in ALI caused by PQ, possibly through inducing Nrf۲/HO-۱ pathway activation.

کلیدواژه ها:

Acute lung injury ، Andrographolide ، Apoptosis ، Nrf۲ ، Oxidative stress ، Paraquat

نویسندگان

Degang Zhang

Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Fengqin Shen

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Shiting Ma

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Suting Nan

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Yanhong Ma

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Lili Ren

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Hao Li

Health Science Center, Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

Qin Yu

Lanzhou University, Lanzhou, Gansu Province, ۷۳۰۰۰۰, P.R. China

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