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مقالات فارسیISIکنفرانسهاژورنالها

Genome editing with the CRISPR/Cas۹ method and production of a laboratory model of beta thalassemia

محل انتشار: دومین کنگره ملی رویکردهای نوآورانه در سیستم بیولوژی و داروسازی
سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 127

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لینک ثابت به این مقاله:
https://civilica.com/doc/1663825

شناسه ملی سند علمی:

IASBP02_019

تاریخ نمایه سازی: 3 خرداد 1402

چکیده مقاله:

Beta-thalassemia are a group of hereditary blood disorders caused by mutations in the β-globin gene (HBB) cluster resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The aim of this study was the production of an in vitro model of β-thalassemia using the CRISPR/Cas۹ as a easily programmable, fast, more powerful, and efficient technique

کلیدواژه ها:

Beta‐thalassemia ، CRISPR‐Cas۹ system ، Erythroid differentiation ، Hbb‐b۱ ، Mouse embryonic stem cell

نویسندگان

Omid Moeini

Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Mansoureh Ajami

Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran

Amir Atashi

Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran

Masoud Soleimani

Department of Hematology and Blood Banking, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Monireh Ajami

Department of Hematology, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran