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مقالات فارسیISIکنفرانسهاژورنالها

Emerging Nano-Theranostic Strategies Against Non-Alcoholic Fatty Liver Disease: A review

محل انتشار: مجله علم مواد و مهندسی ایران، دوره: 20، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 121

فایل این مقاله در 28 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1664873

شناسه ملی سند علمی:

JR_IJMSEI-20-1_004

تاریخ نمایه سازی: 6 خرداد 1402

چکیده مقاله:

As a major global cause of liver disease, non-alcoholic fatty liver disease (NAFLD) is characterized by excessive hepatocellular accumulation of lipids in the liver, elevated levels of hepatic enzymes, and fibrotic evidence. The primary therapies for NAFLD are changing lifestyle or managing comorbid-associated diseases. Lately, nanotechnology has revolutionized the art of nanostructure synthesis for disease imaging, diagnosis, and treatment. Loading drugs into nanocarriers has been established as a promising strategy to extend their circulating time, particularly in treating NAFLD. In addition, considering a master modulator of adipogenesis and lysosomal biogenesis and function, designing novel nanostructures for biomedical applications requires using biodegradable materials. Various nanostructures, including inorganic nanoparticles (NPs), organic-based NPs, metallic nanocarriers, biodegradable polymeric nanocarriers, polymer-hybrid nanocarriers, and lipid-based nanocarriers have been designed for NAFLD treatment, which significantly affected serum glucose/lipid levels and liver function indices. NPs modified with polymers, bimetallic NPs, and superparamagnetic NPs have been used to design sensitive nanosensors to measure NAFLD-related biomarkers. However, certain limitations are associated with their use as diagnostic agents. The purpose of this review article is to shed light on the recent advancements in the field of nanomedicine for the early diagnosis, treatment, and prognosis of this progressive liver disease.

کلیدواژه ها:

Biomaterials ، Nanomaterials ، Drug delivery ، Nanotechnology ، Non-alcoholic fatty liver disease (NAFLD).

نویسندگان

Saman Sargazi

Zahedan University of Medical Sciences

Mahtab Ghasemi Toudeshkchouei

University of Tehran

Abbas Rahdar

University of Zabol

Aisha Rauf

Grand Asian University, Sialkot Pakistan Quaid I Azam University

Soheil Amani

Institute for Advanced Studies in Basic Sciences (IASBS)

Razieh Behzadmehr

Department of Radiology, Zabol university of medical sciences

Ana M. Diez-Pascual

Universidad de Alcalá

Francesco Baino

Politecnico di Torino

Muhammad Bilal

School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian ۲۲۳۰۰۳, China

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