Neuroprotective Potential of Trans-Anethole Following Crush Injury of the Sciatic Nerve in Rats
محل انتشار: مجله جراحی مغز و اعصاب ایران، دوره: 9، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 68
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شناسه ملی سند علمی:
JR_IJN-9-1_012
تاریخ نمایه سازی: 8 خرداد 1402
چکیده مقاله:
Background and Aim: Sciatic nerve injury is a common condition that can lead to significant functional deficits. Although current treatments are effective in reducing symptoms, more effective and safer treatments are still required. In this research, the effect of trans-anethole (TA) was investigated on improving the sciatic nerve function in a rat model.
Methods and Materials: Twenty-eight adult male Wistar rats were divided into four groups. Animals were subjected to deep anesthesia. Then, to create a model of the sciatic nerve, the right leg of the rats was compressed above the location of the trifurcation of the nerve. The control and negative groups received saline. Trans-anethole ۱۲۵ mg/kg and ۲۵۰ mg/kg were injected intraperitoneally into two groups of the sciatica model. Finally, muscle histological changes were evaluated.
Results: The results indicated that the injection of TA improved motor recovery in rats. The highest recovery rate was related to the dose of ۲۵۰ mg/kg. The morphometric analysis suggested that the number of fibers and the thickness of the myelin sheath were significantly higher in the group treated with TA compared with the control group. An increase in muscle mass and a decrease in muscle atrophy were observed in the groups treated with TA compared with the negative control group.
Conclusion: These data showed that TA improves nerve damage and can be used as an option to improve inflammation-induced sciatica.
کلیدواژه ها:
نویسندگان
Zahra Naseri
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Fariba Mamoudi
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
Arash Abdolmaleki
۱. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran AND Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran
Milad Soluki
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran