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مقالات فارسیISIکنفرانسهاژورنالها

Neonatal Intestinal Colonization with Extended-Spectrum B-Lactamase-Producing Enterobacteriaceae: Molecular Analysis and Risk Factors in NICU neonates

محل انتشار: مجله بین المللی کودکان، دوره: 11، شماره: 5
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 107

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1672028

شناسه ملی سند علمی:

JR_INJPM-11-5_003

تاریخ نمایه سازی: 17 خرداد 1402

چکیده مقاله:

Background: The goal of this project was to assay the prevalence of fecal carriage of ESΒL-producing Enterobacteriaceae (ESΒL-PE), and to identify the risk factors for carriage in neonates hospitalized in a Neonatal Intensive Care Unit (NICU) of an educational therapeutic hospital (Vali-e-Asr) of Birjand city, east of Iran.Methods: Rectal swabs were taken from ۲۰۰ neonates at the beginning of hospitalization, every week in case of hospitalization and at the time of discharge. Bacterial isolates were identified using different biochemical experiments. Screening of ESΒL-PE was first done by phenotypic test (DD test) and then antibiotic resistance genes were detected by PCR assay.Results: In our research, ۴۲ Enterobacteriaceae were obtained from ۲۰۰ neonates. The total prevalence rate of neonatal rectal carriage of ESΒL-PE was ۴۲/۲۰۰ (۲۱%), mostly Escherichia coli, ۱۸ (۴۲.۸%). blaCTX-M and blaCTX-M-۱۵ were the most prevailing β-lactamase-encoding genes recognized by PCR tests. Intestinal carriage of ESβL among neonates displayed a statistically significant relationship with the use of the mechanical ventilation (p=۰.۰۲۵), APGAR score (p=۰.۰۰۵) and gestational age (weeks) (p=۰.۰۴۴).Conclusion: Our findings highlighted the importance of consistent screening for resistant ESΒL-PE among neonates (especially preterm newborns) and minimizing invasive ventilation whenever possible.

کلیدواژه ها:

Neonate ، ، ، ، ، Enterobacteriaceae ، ، ، ، ، NICU ، ، ، ، ، extended-spectrum beta-lactamase ، ، ، ، ، intestinal carriage ، ، ، ، ، Iran

نویسندگان

Parvin Askari

Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Atiyeh Khosravi

Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

Sedigheh Rastaghi

Ph.D Candidate, Student Research Committee, Department of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Gholamreza Faal

Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences, South Khorasan Province, Birjand, Iran

Mohammad Hasan Namaei

Department of Medical Microbiology, School of Medicine, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

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