The effect of single dose Tranexamic acid on hemorrhagia during abdominal hysterectomy

Background & Objective: Hysterectomy is the most common gynecological surgery. Every year, numerous women around the world undergo this type of surgery for various reasons. Regardless of the type of surgery, bleeding during surgery and after surgery is the most common consequence? Tranexamic acid is a cheap, available and low-complication drug that has been considered in recent years to control bleeding. The present study investigated the effectiveness of Tranexamic acid on the bleeding during laparotomy hysterectomy in women aged ۳۵ to ۵۵ years. Materials & Methods: This study was a randomized, double-blind clinical trial performed on ۸۰ patients undergoing laparotomy hysterectomy. Using a random number table, patients were divided into two groups A (receiving Transid) and the other group receiving drug B (not receiving Transid), both of which received ۱۰۰ ml of normal saline prepared to reduce bias in the prepared syringe. Results: Mean age of the patients was ۴۶.۲۴ ± ۵.۲۱ years. Based on the results of mean hemoglobin before surgery, the rate of infection, infusion and induction in the control and intervention groups were not statistically different (P > ۰.۰۵). Also, the mean hemoglobin variables before and after hemorrhage were estimated by the surgeon and hemorrhage estimated according to Hernandez formula were not statistically different in the two groups (P > ۰.۰۵). Conclusion: Tranexamic acid administration has no effect on the amount of bleeding during hysterectomy laparotomy.