Does dual trigger improve euploidy rate in normoresponder? A cross-sectional study

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 103

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شناسه ملی سند علمی:

JR_IJRM-21-5_004

تاریخ نمایه سازی: 28 خرداد 1402

چکیده مقاله:

Background: With the introduction of the dual triggering-gonadotropin-releasing hormone (GnRH) analog and recombinant human chorionic gonadotropin (hCG) combination, women with a history of low mature oocyte proportion and empty follicle syndrome were shown to benefit from the dual trigger. Objective: To investigate whether dual triggering of oocyte maturation with a GnRH agonist (GnRHa) combined with hCG can affect the euploidy rate and improve in vitro fertilization outcomes for normoresponder women. Materials and Methods: In this cross-sectional study, ۴۹۴ women who underwent controlled ovarian stimulation with hCG (n = ۲۷۴) or dual triggering (hCG+GnRHa, n = ۲۲۰) at Acibadem Maslak hospital, Assisted Reproductive Unit, from January ۲۰۱۹-۲۰۲۲ were enrolled in this study. Preimplantation genetic testing for aneuploidy was performed on all participants. Results: Both groups had similar baseline and clinical characteristics. Of the ۸۸۱ embryos biopsied, ۳۱۲ (۳۵.۴%) were reported as euploid in the hCG trigger group; in the dual trigger group, ۱۸۶ (۲۹.۸%) of ۶۲۳ screening embryos were reported as euploid. The hCG group had a higher euploidy rate per biopsied embryo, although the difference was not statistically significant (۳۱.۴ ± ۲۶.۵ vs. ۲۶.۵ ± ۳۳.۳, p > ۰.۰۵). Conclusion: In normoresponders, adding GnRHa for final follicular maturation to hCG did not improve the euploidy rate.

نویسندگان

Sule Yildirim Kopuk

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.

Zeynep Ece Utkan Korun

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.

Aysen Yuceturk

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.

Ozge Karaosmanoglu

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.

Caglar Yazicioglu

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.

Bulent Tiras

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey. Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Yigit Cakiroglu

Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey. Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

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