Thyroid Receptor Antibody and the Development of Graves’ Orbitopathy: Clinical Experience of using Radioiodine Ablation in the Management of Graves’ Orbitopathy in post-iodine ablation hypothyroid patient
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 73
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شناسه ملی سند علمی:
JR_JNMB-11-2_012
تاریخ نمایه سازی: 28 خرداد 1402
چکیده مقاله:
Graves’ disease (GD) is the commonest cause of hyperthyroidism, accounted for ۷۰-۸۰% in iodine sufficient countries and up to ۵۰% in iodine deficient countries. Combination of genetic predisposition and environmental factors influences the development of GD. Graves’ orbitopathy (GO) represents the most common extra-thyroidal manifestation of GD with substantial impact on morbidity and quality of life. Expression of thyroid stimulating hormone receptor (TSHR) mRNA and protein in orbital tissues infiltrated by the activated lymphocytes produced by thyroid cells (Thyroid Receptor Antibody) results in the secretion of inflammatory cytokines that leads to the development of histological and clinical characteristics of GO. A subdivision of TRAb, thyroid stimulating antibody (TSAb), was found to have a close relationship with the activity and severity of GO, and suggested to be considered as a direct parameter of GO. Here, we present a ۷۵-year-old female with a history of GD that has successfully been treated with radioiodine treatment, who developed GO ۱۳ months after therapy while being hypothyroid with high TRAb level. The patient was given a second dose of radioiodine ablation to maintain GO with successful result.
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نویسندگان
Edelyn Christina
Department of Nuclear Medicine, Padjadjaran University, Bandung, Indonesia
Hendra Budiawan
Department of Nuclear Medicine, Padjadjaran University, Bandung, Indonesia
Hapsari Indrawati
Department of Nuclear Medicine, Mochtar Riady Comprehensive Cancer Center Siloam Hospital, Jakarta, Indonesia
Erwin Soeriadi
Department of Nuclear Medicine, Hasan Sadikin Central Hospital, Bandung, Indonesia
Trias Nugrahadi
Department of Nuclear Medicine, Hasan Sadikin Central Hospital, Bandung, Indonesia
A Hussein Kartamihardja
Department of Nuclear Medicine, Hasan Sadikin Central Hospital, Bandung, Indonesia
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