Tissue Substitute Materials for the Human Colorectal Cancer Tissue
محل انتشار: مجله فیزیک پزشکی ایران، دوره: 20، شماره: 3
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 57
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شناسه ملی سند علمی:
JR_IJMP-20-3_003
تاریخ نمایه سازی: 30 خرداد 1402
چکیده مقاله:
Introduction: Due to the high radiation dose used in radiotherapy, the human tissue is usually replaced with tissue substitutes in order to develop new treatment techniques. Tissue substitutes have not been reported for colorectal cancer tissue (CRC). This study aims at developing tissue substitutes for the CRC tissue with respect to the mass attenuation (µm) and mass energy absorption coefficients (µen/ρ) within the energy range of ۶ – ۱۵MV. Material and Methods: Colorectal cancer tissue and four locally sourced materials namely beeswax, gelatine, rice powder, clay, and their mixtures – Clarice, gelarice, gelaclay, and bewaclay were subjected to Rutherford Backscattering Spectrometry (RBS) to determine their elemental composition. Results from the RBS were used in XCOM, a web-based photon interaction software designed by the National Institute of Standards and Technology, USA to determine their theoretical µm and µen/ρ values. Again, these materials were exposed to a narrow beam of x-rays at energies of ۶ and ۱۵MV to obtain their experimental µm and µen/ρ values. Results: Revealed that the ratio of CRC tissue to the test materials ranged from ۰.۹۴۶ (beeswax) to ۱.۰۷ (clay) for both theoretical and experimental values with bewaclay having a ratio of ۱.۰۱ compared with ۱.۰۰ for CRC and a p = ۰.۵۴۱ and p = ۰.۶۶۳ with respect to µm and µen/ρ respectively. Conclusion: Bewaclay with the closest match can be used as a tissue substitute for the CRC tissue between ۶ – ۹MV with respect to µm and µen/ρ as parameters for matching.
کلیدواژه ها:
نویسندگان
Emmanuel Esien-umo
Department of Radiography and Radiological Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Cross River State
Joseph Obu
Department of Physics, Faculty of Physical Sciences, University of Calabar
Ndubuisi Chiaghanam
Department of Radiography and Radiological Science, University of Calabar, Calabar-Nigeria
Akwa Erim
Department of Radiography and Radiological science, Faculty of allied medical sciences, University of Calabar, Calabar, Cross River State, Nigeria
Nneoyi Egbe
Department of Radiography & Radiological Science, University of Calabar, Nigeria
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