Implementation of the Electrochemical Impedance Method for Measuring Troponin Enzyme in the Laboratory on a Chip
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 166
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شناسه ملی سند علمی:
JR_JABR-10-1_008
تاریخ نمایه سازی: 6 تیر 1402
چکیده مقاله:
Introduction: Troponin enzyme is a gold biomarker for detecting heart attacks. IF it is possible to measure blood troponin levels at the onset of heart pain or symptoms of myocardial infarction, heart damage can be determined by measuring how much it changes. Diagnostic kits are available on the market to detect the presence of enzymes in the blood, but these kits do not check the extent of enzymatic changes. Actually, these kits only check for more than a certain amount of enzyme in the blood. Many experiments can be performed with the advent of lab-onchips.Materials and Methods: In the proposed method, the troponin enzyme is separated from the rest of the blood by the selected aptamer and then the concentration of the troponin enzyme in the sample is measured by the electrochemical impedance method and Arduino board and coding. The Arduino software was used for coding and simulation, and electrochemical spectroscopy was performed by simulating the behavior of an electrochemical sensor.Results: According to the findings of the present study, the initial measurement by the device showed an error of ۵۵%, which was reduced to ۱۳.۵% in the measurement by changing the measuring factors.Conclusions: The manufactured device has the ability to receive the sample, separate it into essential and non-essential components, extract the required information from the sample and also analyze the obtained information. However, the electronic structural factors of the device such as resistance, etc. but must be changed in order to reach ۹۵% reliability.
کلیدواژه ها:
نویسندگان
Sajedeh Sajedeh Jafarypour
Department of Industrial Engineering, Faculty of Engineering, Sistan and Baluchestan University, Sistan and Baluchestan, Iran
Mohebali Rahdar
Department of Industrial Engineering, Faculty of Engineering, Sistan and Baluchestan University, Sistan and Baluchestan, Iran
Gholamreza Farnoosh
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran