Combination Therapy of ReciGen Interferon, Methylprednisolone, and Sovodak as a Candidate for Treatment of Patients With Severe COVID-۱۹ in Iran: A Case Series

Introduction: During the current worldwide pandemic of coronavirus disease ۲۰۱۹ (CPVID-۱۹), this disease was first identified in Iran at the end of February. This study was conducted to examine patients with severe COVID-۱۹ disease, who were treated with three medications, namely ReciGen, methylprednisolone, and Sovodak.Case Presentation: We identified ۱۰ patients (۳ males and ۷ females) with the mean (± SD) age of ۵۵.۷۰ ± ۲۱.۴۸ years, who were admitted to the only referral hospital in Rafsanjan County (Iran) from March to July ۲۰۲۰ with confirmed infections with severe COVID-۱۹. They were treated with the combination therapy of subcutaneous ReciGen interferon every other day, methylprednisolone at a dose of ۲۵۰ mg every ۶ hours for ۵ days, and one tablet of Sovodak daily.Conclusion: In the series of cases investigated in this study, the general conditions of all patients improved in terms of their clinical parameters after receiving the combination therapy, and all patients were discharged with a blood oxygen level of ≥ ۹۳% and in good general conditions.