Prevalence of Microorganisms and Antibiotic Sensitivity Among Patients with Diabetic Foot Ulcer in Sulaimani City, Iraq

Background: Diabetic foot ulcers (DFUs) are responsible for days of costly hospitalization and are the major cause of medical lower limb amputations. Determining the appropriate antimicrobial therapy for DFUs is highly dependent on recognizing the microorganisms that cause them. Many reports have indicated that there has been a remarkable increase in antibiotic resistance. Objectives: The present study examined various cultures of patients with DFUs to detect the prevalence of microorganisms and their antibiotic sensitivity profiles. Methods: This cross-sectional study was carried out on ۹۲ patients with DFUs admitted to Shar Teaching Hospital and Shahid Hemin Teaching Hospital. Wagner Classification was used to assess the severity and location of the DFUs. Patients were asked questions about their practices of foot care and hygiene, and their answers were recorded. Samples required for testing were taken using sterile swabs. Results: A total of ۱۰۰ microorganisms were isolated from ۹۲ patients with DFUs, ۱۰ of which were polymicrobial and ۲ were culture-negative. There was a highly significant association between the isolated gram-negative microorganisms and higher grades of DFU (P < ۰.۰۰۱). A highly significant association was also observed between bad patient knowledge of hygiene practices and gram-negative microorganisms (P < ۰.۰۰۱). Osteomyelitis was present in ۴۰ (۴۳.۴%) patients. Conclusion: Among gram-positive and gram-negative bacteria, Staphylococcus spp. and E. coli were, respectively, the most frequent organisms isolated. The antibiotic imipenem was found to be effective against microorganisms. Tetracycline, erythromycin, and ceftriaxone, however, were highly resistant to antibiotics. To sum up, since different microorganisms are involved and multidrug-resistant strains might emerge, clinicians are recommended to take cultures into account before they initiate empirical therapy.