Association between Adiponectin Level and Mean Platelet Volume in Neonates with Respiratory Distress Syndrome: A Prospective Cohort Study

Background: Respiratory distress is a serious condition affecting preterm neonates. The present study was designed to evaluate the association between mean platelet volume (MPV) and adiponectin (APN) levels and the development of respiratory distress syndrome (RDS) in preterm neonates. Methods: This prospective cohort study was conducted at a tertiary hospital. The target population was preterm neonates (≤ ۳۴ weeks) admitted to the incubator and diagnosed with RDS. A control group was recruited and composed of age-matched neonates seen at the delivery room and required no admission or ventilatory support. Blood samples were withdrawn on days ۱ and ۷ of life for a complete blood count and another one for APN level measurement . Results: The study group showed a higher MPV at day ۱ and day ۷ than the control group (P<۰.۰۰۱) and lower mean APN at day ۱ and day ۷ than the control group (P<۰.۰۰۱). The MPV had cut-off levels of more than ۷.۷ (sensitivity of ۸۶.۹۶% and specificity of ۱۰۰%) and ۸.۱۵ (sensitivity of ۷۸.۲۶% and specificity of ۹۱.۳%) on days ۱ and ۷, respectively, to predict RDS. The APN had cut-off levels ≤ ۳۷ (sensitivity of ۸۶.۹۶% and specificity of ۶۰.۸۷%) and ≤ ۲۲.۴ (sensitivity of ۸۲.۶۱% and specificity of ۶۹.۵۷%) on days ۱ and ۷, respectively, to predict RDS. Conclusion: Based on the findings of the present research, the MPV significantly increased while APN levels were lower in preterm neonates with RDS. Both markers predicted RDS development significantly.