Association of angiotensin-converting enzyme gene variations with coronary artery disease in the Iranian population

Background: The purpose of this study was to identify the angiotensin-converting enzyme (ACE) gene (I/D) variations in CAD patients and healthy controls in an Iranian population (West Azerbaijan province of Iran).Methods: This cross-sectional study included ۹۵ CAD patients and ۲۰۳ healthy controls. ACE I/D polymorphisms were assessed using PCR, and their frequency was determined. Results: There were ۲۹۸ people, ۹۵ CAD patients, and ۲۰۳ controls, with an average age of ۵۰.۹۶±۳.۴۵ and ۵۱.۱۴±۱۰.۲۰. We discovered that the frequency of the D allele was significantly higher in CAD patients than in controls (P = ۰.۰۰۰۹). In contrast, the frequency of the I allele was significantly higher in controls than in CAD patients (P = ۰.۰۰۰۹). The D allele carriers genotypes (DD + ID) were more frequent in the CAD patients than in the control group (P = ۰.۰۰۸). The ACE II genotype-state carriers were more common in the control group than in CAD patients (P = ۰.۰۰۸۴). However, in the case of the ACE ID genotype, no significant differences were not found in the tested groups (P = ۰.۴۷).Conclusions: These findings suggest that individuals with the ACE DD genotype are predisposed to CAD, whereas individuals with the ACE II genotype state are protected.