Hydrogels reinforced with TiO۲-NPs for wound healing application

Full-thickness wounds are a growing problem due to their high costs and complications. Despite recent advances in wound healing, several systemic and local factors can impair the physiological healing process. This article briefly examines the role of titanium dioxide nanoparticles in the healing wound process. Hydrogels are a type of scaffold with ۳D networks that are widely used for tissue regeneration. Hydrogels have a porous structure containing macromolecules or polymers that can easily swell in water. Nano-based materials have unique physicochemical, optical, and biological properties compared to their bulk counterparts. Nanoparticles can be incorporated into scaffolds to create smart nanocomposite materials that improve wound healing through antimicrobial properties as well as anti-inflammatory and selective angiogenic properties. Nanoparticles have been used for drug delivery due to their high surface area. In addition, nanoparticles affect wound healing by influencing collagen deposition and reorganization, providing approaches for skin regeneration and wound healing. Titanium dioxide nanoparticles (TiO۲-NPs) is a metal oxide nanoparticle that has recently received attention in biomedical applications due to their non-toxicity, antibacterial activity, and chemical stability. Research into wound healing applications has led to reports of accelerated wound healing and ingrowth of vascular tissue.