Effect of Liquorice-Extract-Containing Antimicrobial Mouthwash on Helicobacter Pylori: An In Vitro Study
محل انتشار: مجله تحقیقات دندانپزشکی، دوره: 14، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 73
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شناسه ملی سند علمی:
JR_AJDR-14-4_004
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background: The oral route is one of the main portals for Helicobacter pylori transmission. The elimination
of this bacterial species from the oral cavity might be useful in oral health and decreasing infections due to
H. pylori. This study aimed to evaluate the effect of a liquorice-extract-containing mouthwash at different
concentrations on the proliferation of H. pylori in vitro.
Methods: H. pylori bacterial species was cultured, and the isolated strains from the specific culture medium
were prepared for the welling procedures. The liquorice (Glycyrrhiza glabra) mouthwash at ۱۲.۵% and
۲۵% concentrations was added to the case group wells at ۱,۱/۲,۱/۴,۱/۸, and ۱/۱۶ dilutions. In the control
group, regular daily mouthwash containing cetylpyridinium chloride and sodium fluoride components
was used. The growth inhibition zones were analyzed in the study groups. The data were analyzed by SPSS
and reported using descriptive statistics (means ± standard deviation).
Results: In both the mouthwashes containing ۲۵% and ۱۲.۵% concentration, the means of growth
inhibition zones at ۱, ۱/۲, ۱/۴, ۱/۸, and ۱/۱۶ dilutions were larger than those in the control group. Further,
the largest growth inhibition zone was seen with the undiluted ۲۵% mouthwash. There were no significant
differences in the H. pylori growth inhibition zones between ۲۵% and ۱۲.۵% mouthwashes (P = ۰.۱۴).
Conclusions: Mouthwashes containing liquorice extracts inhibited the growth of H. pylori more significantly
than mouthwash with no liquorice extract. Therefore, it is suggested that liquorice extract-containing
mouthwashes be used to prevent H. pylori infections in the oral cavity in clinical studies.
کلیدواژه ها:
نویسندگان
Sepideh Bohlouli
Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
Mahdiyeh Esmaeilzadeh
Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Hossein Samadi Kafil
Drug Applied Research Center, Department of Microbiology, Tabriz University of Medical Sciences, Tabriz, Iran
Ramin Negahdari
Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran