Potential Drug-Drug Interactions in Patients Using Warfarin, Heparin, and Enoxaparin
محل انتشار: مجله تحقیقات دارویی ابن سینا، دوره: 2، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 104
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شناسه ملی سند علمی:
JR_AJPR-2-2_004
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background: Drug-drug interactions can often lead to preventable adverse drug events and
hospitalization. However, the clinical outcome of a potential drug-drug interaction that may
range from minor alterations to major toxicity or loss of effect is often unknown. Drugs with
narrow therapeutic index are more susceptible to the outcomes of interactions. Anticoagulants
are one of the drug groups prone to drug-drug interactions and have important side effects. in
this retrospective study, the frequency of drug-drug interactions involving warfarin, heparin and
enoxaparin was investigated.
Methods: Overall, ۳۰۰ patients (including ۵۵% males with an average age of ۵۰.۷۵ years) participated
in this study, and for each anticoagulant, ۱۰۰ patient orders were randomly selected from the hospital
system. Drug-drug interactions were evaluated using the Micromedex drug interaction checker.
Results: A total of ۱۶۹۱ drug-drug interactions (۳۰۶ major, ۲۵۳ moderate, and ۸۹ minor interactions)
were recorded of which only ۶۴۸ (average ۲.۱۶) involved warfarin, heparin, or enoxaparin. Most
interactions were recorded in patients admitted to the cardiovascular surgery (n=۳۱۲) and cardiology
(n=۱۱۹) wards. There was a significant relationship between the number of drugs and the frequency
of interaction. warfarin had the highest number of interactions (n=۳۸۸).
Conclusion: The frequency of drug interactions is high in patients on anticoagulant therapy.
The efficacy and safety of these drugs can be affected by drug interactions. Accordingly, these
interactions should always be considered, especially in patients with multiple drug use. Efficient
monitoring strategies should be employed to optimize treatment while reducing adverse effects.
کلیدواژه ها:
نویسندگان
Cengizhan Ceylan
Department of Clinical Pharmacy, Faculty of Pharmacy, Selcuk University, Konya, Turkey
Rashida Muhammad Umar
Department of Clinical Pharmacy, School of Pharmacy, İstanbul Medipol University, Istanbul, Turkey
Büşra Nur Çattık
Department of Clinical Pharmacy, School of Pharmacy, İstanbul Medipol University, Istanbul, Turkey
Fatih Bolel
Department of Clinical Pharmacy, School of Pharmacy, İstanbul Medipol University, Istanbul, Turkey