The Genetic Basis of Hypertension: An Overview
محل انتشار: مجله تحقیقات دارویی ابن سینا، دوره: 2، شماره: 2
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 104
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شناسه ملی سند علمی:
JR_AJPR-2-2_008
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
In light of the widespread recognition of the heritability of hypertension (HTN), numerous studies have
been conducted to better understand the pathogenesis of different variants of HTN and their interactions.
The complexity of crucial HTN makes it difficult to segregate and identify particular genes that influence
blood pressure (BP) fluctuation, making the development of single-gene targeted treatments tough.
Therefore, finding HTN susceptibility genes will contribute to the understanding of the biology behind the
disease. Apart from its potential impact on antihypertensive drug therapy selection, genomic information
may also contribute to identifying persons at risk of developing the condition, resulting in new preventative
strategies. It is necessary to conduct more replication studies in other populations to confirm that there is a
link between certain genetic variations and the varying response to these frequently used antihypertensive
medications. Moreover, antihypertensive medication responsiveness to epigenetics and regulatory
networks may be improved by further research. This may aid researchers to find new HTN therapeutic
targets. This study aimed to come up with a list of known genetic variants that may play a role in HTN.
کلیدواژه ها:
نویسندگان
Fahmida Yesmin
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Arifa Sultana
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Ananya Saha
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Tahmina Akter
Department of Physiology, Dhaka Medical College, Dhaka ۱۰۰۰, Bangladesh